LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice

被引:108
作者
Faggioni, R
Fuller, J
Moser, A
Feingold, KR
Grunfeld, C
机构
[1] VET ADM MED CTR, METAB SECT 111F, MED SERV, SAN FRANCISCO, CA 94121 USA
[2] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94121 USA
关键词
endotoxin; infection; inflammation;
D O I
10.1152/ajpregu.1997.273.1.R181
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Administration of endotoxin (lipopolysaccharide, LPS) induces profound anorexia. Injection of leptin decreases food intake in mice. Recently, we reported that LPS and cytokines increase leptin levels in hamsters. To further investigate the role of leptin in the LPS-induced anorexia, we administered LPS to leptin receptor-deficient (db/db) and leptin-deficient (ob/ob) mice. We found that LPS caused anorexia in both db/db and ob/ob mice. As might be predicted if leptin had a role in anorexia, the db/db mice were somewhat resistant to LPS-induced anorexia. However the ob/ob mice were more sensitive to LPS-induced anorexia. No differences between db/db and ob/ob mice and their respective littermate were observed in circulating tumor necrosis factor levels after LPS. These data suggest that leptin per se is not essential for LPS-induced anorexia.
引用
收藏
页码:R181 / R186
页数:6
相关论文
共 32 条
[11]   DEFECTIVE INFLAMMATORY RESPONSE IN INTERLEUKIN 6-DEFICIENT MICE [J].
FATTORI, E ;
CAPPELLETTI, M ;
COSTA, P ;
SELLITTO, C ;
CANTONI, L ;
CARELLI, M ;
FAGGIONI, R ;
FANTUZZI, G ;
GHEZZI, P ;
POLI, V .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1243-1250
[12]   EXPRESSION OF OB MESSENGER-RNA AND ITS ENCODED PROTEIN IN RODENTS - IMPACT OF NUTRITION AND OBESITY [J].
FREDERICH, RC ;
LOLLMANN, B ;
HAMANN, A ;
NAPOLITANOROSEN, A ;
KAHN, BB ;
LOWELL, BB ;
FLIER, JS .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (03) :1658-1663
[13]   LEPTIN LEVELS REFLECT BODY LIPID-CONTENT IN MICE - EVIDENCE FOR DIET-INDUCED RESISTANCE TO LEPTIN ACTION [J].
FREDERICH, RC ;
HAMANN, A ;
ANDERSON, S ;
LOLLMANN, B ;
LOWELL, BB ;
FLIER, JS .
NATURE MEDICINE, 1995, 1 (12) :1311-1314
[14]   Defective STAT signaling by the leptin receptor in diabetic mice [J].
Ghilardi, N ;
Ziegler, S ;
Wiestner, A ;
Stoffel, R ;
Heim, MH ;
Skoda, RC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6231-6235
[15]  
GRUNFELD C, 1989, CANCER RES, V49, P2554
[16]   Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters - A role for leptin in the anorexia of infection [J].
Grunfeld, C ;
Zhao, C ;
Fuller, J ;
Pollock, A ;
Moser, A ;
Friedman, J ;
Feingold, KR .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (09) :2152-2157
[17]   THE METABOLIC EFFECTS OF TUMOR-NECROSIS-FACTOR AND OTHER CYTOKINES [J].
GRUNFELD, C ;
FEINGOLD, KR .
BIOTHERAPY, 1991, 3 (02) :143-158
[18]   WEIGHT-REDUCING EFFECTS OF THE PLASMA-PROTEIN ENCODED BY THE OBESE GENE [J].
HALAAS, JL ;
GAJIWALA, KS ;
MAFFEI, M ;
COHEN, SL ;
CHAIT, BT ;
RABINOWITZ, D ;
LALLONE, RL ;
BURLEY, SK ;
FRIEDMAN, JM .
SCIENCE, 1995, 269 (5223) :543-546
[19]   Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice [J].
Lynn, RB ;
Cao, GY ;
Considine, RV ;
Hyde, TM ;
Caro, JF .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 219 (03) :884-889
[20]   LEPTIN LEVELS IN HUMAN AND RODENT - MEASUREMENT OF PLASMA LEPTIN AND OB RNA IN OBESE AND WEIGHT-REDUCED SUBJECTS [J].
MAFFEI, M ;
HALAAS, J ;
RAVUSSIN, E ;
PRATLEY, RE ;
LEE, GH ;
ZHANG, Y ;
FEI, H ;
KIM, S ;
LALLONE, R ;
RANGANATHAN, S ;
KERN, PA ;
FRIEDMAN, JM .
NATURE MEDICINE, 1995, 1 (11) :1155-1161