Calcium channel blockers and cancer

被引：18

作者：

Cohen, HJ

Pieper, CF

Hanlon, JT

Wall, WE

Burchett, BM

Havlik, RJ

机构：

[1] Duke Univ, Med Ctr, Ctr Study Aging & Human Dev, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Div Geriatr, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Med, Div Gen Internal Med, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Dept Family Med, Div Biometry, Durham, NC 27710 USA

[5] Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Durham, NC 27705 USA

[6] Univ Minnesota, Coll Pharm, Minneapolis, MN 55455 USA

[7] NIA, Epidemiol Demog & Biometry Program, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF MEDICINE | 2000年 / 108卷 / 03期

关键词：

D O I：

10.1016/S0002-9343(99)00447-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

PURPOSE: We sought to explore the relation that has been previously reported between calcium channel blockers and an increased risk of cancer. SUBJECTS AND METHODS: We followed 3,511 participants, age 65 years or older, in the Duke Established Populations for Epidemiologic Studies of the Elderly for up to 10 years. Information about use of medications was obtained at baseline and 3 and 6 years later. Information about hospitalization for cancer, or death from cancer, was obtained from Health Care Financing Administration data and death certificates. RESULTS: Of the 133 users of calcium channel blockers, 16 (12%) developed cancer, compared with 548 (16%) of 3,378 nonusers (hazard ratio = 0.9; 95% confidence interval, 0.5 to 1.5). Adjusting for baseline and time-dependent covariates, such as race, diabetes, or blood pressure, for dose or class of calcium channel blockers, or for length of follow-up, had no effect. CONCLUSIONS: Use of calcium channel blockers does not appear to be related to cancer risk. Earlier reports showing such a relation may have been the result of chance. (C) 2000 by Excerpta Medica, Inc.

引用

页码：210 / 215

页数：6

共 28 条

[1] THE ASSOCIATION OF AGE AND DEPRESSION AMONG THE ELDERLY - AN EPIDEMIOLOGIC EXPLORATION [J].