P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer

被引：164

作者：

Graus, F

Lang, B

Pozo-Rosich, P

Saiz, A

Casamitjana, R

Vincent, A

机构：

[1] Univ Barcelona, Hosp Clin Barcelona, Serv Neurol, E-08036 Barcelona, Spain

[2] Univ Barcelona, Hosp Clin Barcelona, Hormonal Lab, E-08036 Barcelona, Spain

[3] IDIBAPS, Barcelona, Spain

[4] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Neurosci Grp, Oxford OX3 9DU, England

来源：

NEUROLOGY | 2002年 / 59卷 / 05期

关键词：

D O I：

10.1212/WNL.59.5.764

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Raised levels of P/Q type voltage-gated calcium-channel (VGCC) antibodies were found in 16 (41%) of 39 patients with paraneoplastic cerebellar degeneration (PCD) and Hu antibodies were found in nine (23%). Seven of the 16 VGCC antibody-positive patients had Lambert-Eaton myasthenic syndrome (LEMS). Seven of 15 CSF samples had VGCC antibodies, with evidence of intrathecal synthesis in four. VGCC antibodies should be looked for in PCD, even if there are no symptoms of LEMS, and may be related to the cerebellar dysfunction.

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页码：764 / 766

页数：3

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