Circulating tumor cells and circulating tumor DNA: What surgical oncologists need to know?

被引：46

作者：

Cabel, L. ^{[1
,2
]}

Proudhon, C. ^{[2
]}

Mariani, P. ^{[3
]}

Tzanis, D. ^{[3
]}

Beinse, G. ^{[1
]}

Bieche, I. ^{[4
,5
]}

Pierga, J. -Y. ^{[1
,2
,5
]}

Bidard, F. -C. ^{[1
,2
,6
]}

机构：

[1] PSL Res Univ, Inst Curie, Dept Med Oncol, Paris, France

[2] PSL Res Univ, Inst Curie, Circulating Tumor Biomarkers Lab, SiRIC, Paris, France

[3] PSL Res Univ, Inst Curie, Dept Surg Oncol, Paris, France

[4] PSL Res Univ, Inst Curie, Dept Genet, Paris, France

[5] Univ Paris 05, Paris, France

[6] Univ Paris Saclay, St Cloud, France

来源：

EJSO | 2017年 / 43卷 / 05期

关键词：

Circulating tumor cells; Circulating tumor DNA; Neoadjuvant; Surgery; Minimal residual disease; POLYMERASE-CHAIN-REACTION; MESSENGER-RNA EXPRESSION; ADVANCED RECTAL-CANCER; PRIMARY BREAST-CANCER; STAGE-III MELANOMA; PERIPHERAL-BLOOD; CARCINOEMBRYONIC ANTIGEN; CLINICAL-SIGNIFICANCE; COLORECTAL-CANCER; NEOADJUVANT CHEMOTHERAPY;

D O I：

10.1016/j.ejso.2017.01.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

As a result of recent progress in detection techniques, circulating tumor DNA (ctDNA) and circulating tumor cells (CTC) can now be accurately detected in the blood of most cancer patients. While these new biomarkers can provide a better understanding of key biological mechanisms underlying cancer growth and dissemination, they also open up a wide range of possible clinical applications in medical oncology, radiation oncology and surgical oncology. In this review, we summarize the results obtained with ctDNA and CTC together with their potential future clinical applications in the field of surgical oncology, with particular focus on the perioperative setting of various types of cancer. These applications include, but are not limited to, cancer screening, early diagnosis, prognostic assessment, evaluation and management of preoperative systemic or local therapies, post-surgical detection of minimal residual disease and early detection of cancer relapse. (C) 2017 Elsevier Ltd, BASO - The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

引用

页码：949 / 962

页数：14

共 98 条

[1]

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].

Aceto, Nicola ;

Bardia, Aditya ;

Miyamoto, David T. ;

Donaldson, Maria C. ;

Wittner, Ben S. ;

Spencer, Joel A. ;

Yu, Min ;

Pely, Adam ;

Engstrom, Amanda ;

Zhu, Huili ;

Brannigan, Brian W. ;

Kapur, Ravi ;

Stott, Shannon L. ;

Shioda, Toshi ;

Ramaswamy, Sridhar ;

Ting, David T. ;

Lin, Charles P. ;

Toner, Mehmet ;

Haber, Daniel A. ;

Maheswaran, Shyamala .

CELL, 2014, 158 (05) :1110-1122

[2]

Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy [J].

Alix-Panabieres, Catherine ;

Pantel, Klaus .

CANCER DISCOVERY, 2016, 6 (05) :479-491

[3]

Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases [J].

Allard, WJ ;

Matera, J ;

Miller, MC ;

Repollet, M ;

Connelly, MC ;

Rao, C ;

Tibbe, AGJ ;

Uhr, JW ;

Terstappen, LWMM .

CLINICAL CANCER RESEARCH, 2004, 10 (20) :6897-6904

[4]

[Anonymous], 1948, CR SOC BIOL

[5]

[Anonymous], J UROL, DOI DOI 10.1016/J.JUR0.2008.01.102

[6]

[Anonymous], SABCS ABSTR

[7]

[Anonymous], ANN ONCOL

[8]

[Anonymous], CLIN CHEM

[9]

[Anonymous], 1869, Aust Med J

[10]

[Anonymous], 2014, J NATL CANC I

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