Interleukin-7 and immunorestoration in HIV: Beyond the thymus

被引：20

作者：

Fry, TJ ^{[1
]}

Mackall, CL ^{[1
]}

机构：

[1] NIH, Immunol Sect, Pediat Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH | 2002年 / 11卷 / 05期

关键词：

D O I：

10.1089/152581602760404603

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One of the hallmarks of untreated HIV infection is a progressive loss of effective immunity to both HIV-associated and non-HIV antigens. Combination antiretroviral therapy can frequently control viral replication, resulting in variable levels of immune reconstitution, but has not resulted in restoration of effective immunity to the virus. Understanding the limitations of immune reconstitution following highly active antiretroviral therapy (HAART) and identifying approaches to enhance immunity in this context may not only improve outcome for patients with HIV infection but could also provide insight for immune reconstitution in other conditions associated with T cell depletion.

引用

页码：803 / 807

页数：5

共 26 条

[1]

AbdulHai A, 1996, EXP HEMATOL, V24, P1416

[2] Mechanisms of HIV-associated lymphocyte apoptosis [J].

Badley, AD ;

Pilon, AA ;

Landay, A ;

Lynch, DH .

BLOOD, 2000, 96 (09) :2951-2964

[3] The challenge of viral reservoirs in HIV-1 infection [J].

Blankson, JN ;

Persaud, D ;

Siliciano, RF .

ANNUAL REVIEW OF MEDICINE, 2002, 53 :557-593

[4] T cell responses to recall antigens, alloantigen, and mitogen of HIV-infected patients receiving long-term combined antiretroviral therapy [J].

Blazevic, V ;

Sahgal, N ;

Kessler, HA ;

Landay, AL ;

Shearer, GM .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2000, 16 (17) :1887-1893

[5]

Bolotin E, 1996, BLOOD, V88, P1887

[6] A potential role for interleukin-7 in T-cell homeostasis [J].

Fry, TJ ;

Connick, E ;

Falloon, J ;

Lederman, MM ;

Liewehr, DJ ;

Spritzler, J ;

Steinberg, SM ;

Wood, LV ;

Yarchoan, R ;

Zuckerman, J ;

Landay, A ;

Mackall, CL .

BLOOD, 2001, 97 (10) :2983-2990

[7] Interleukin-7 restores immunity in athymic T-cell-depleted hosts [J].

Fry, TJ ;

Christensen, BL ;

Komschlies, KL ;

Gress, RE ;

Mackall, CL .

BLOOD, 2001, 97 (06) :1525-1533

[8] Interleukin-7: master regulator of peripheral T-cell homeostasis? [J].

Fry, TJ ;

Mackall, CL .

TRENDS IN IMMUNOLOGY, 2001, 22 (10) :564-571

[9] IL-7 administration alters the CD4:CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation [J].

Geiselhart, LA ;

Humphries, CA ;

Gregorio, TA ;

Mou, S ;

Subleski, J ;

Komschlies, KL .

JOURNAL OF IMMUNOLOGY, 2001, 166 (05) :3019-3027

[10] Constraints on CD4 recovery postchemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells [J].

Hakim, FT ;

Cepeda, R ;

Kaimei, S ;

Mackall, CL ;

McAtee, N ;

Zujewski, J ;

Cowan, K ;

Gress, RE .

BLOOD, 1997, 90 (09) :3789-3798

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