MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines

被引：187

作者：

Liu, Xiqiang ^{[1
,2
,3
]}

Jiang, Lu ^{[1
]}

Wang, Anxun ^{[1
,4
]}

Yu, Jinsheng ^{[1
,5
]}

Shi, Fei ^{[1
,5
]}

Zhou, Xiaofeng ^{[1
,6
]}

机构：

[1] Univ Illinois, Coll Dent, Ctr Mol Biol Oral Dis, Chicago, IL 60612 USA

[2] Sun Yat Sen Univ, Guanghua Sch, Guangzhou 510275, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Res Inst Stomatol, Guangzhou 510275, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Dept Oral & Maxillofacial Surg, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China

[5] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL 60612 USA

[6] Univ Illinois, UIC Canc Ctr, Grad Coll, Chicago, IL 60612 USA

来源：

CANCER LETTERS | 2009年 / 286卷 / 02期

关键词：

HNSCC; MicroRNA; miR-138; Metastasis; Invasion; HUMAN BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; DOWN-REGULATION; EXPRESSION; RNA; IDENTIFICATION; PROTEIN; FAMILY; GENES;

D O I：

10.1016/j.canlet.2009.05.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis is a critical event in the progression of head and neck squamous cell carcinoma (HNSCC). To identify microRNAs associated with HNSCC metastasis. six paired HNSCC cell lines with different metastatic potential were examined. Using microarrays, a panel of differentially expressed microRNAs was identified, including reduction of miR-138 in highly metastatic cells. Ectopic transfection of miR-138 suppressed cell invasion and led to cell cycle arrest and apoptosis. Knockdown of miR-138 enhanced cell invasion and suppressed apoptosis. Thus, our results suggested miR-138 acts as a tumor suppresser and may serve as a therapeutic target for HNSCC patients at risk of metastasis. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：217 / 222

页数：6

共 51 条

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