Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers

被引：158

作者：

Suto, Fumikazu

Tsuboi, Miu

Kamiya, Haruyuki

Mizuno, Hidenobu

Kiyama, Yuji

Komai, Shoji

Shimizu, Masayuki

Sanbo, Makoto

Yagi, Takeshi

Hiromi, Yasushi

Chedotal, Alain

Mitchell, Kevin J.

Manabe, Toshiya

Fujisawa, Hajime ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Div Biol Sci, 21st Century COE Program, Nagoya, Aichi 4648602, Japan

[2] Natl Inst Genet, Div Dev Genet, Mishima, Shizuoka 4118540, Japan

[3] Japan Sci & Technol Agcy, CREST, Kawaguchi 3320012, Japan

[4] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Grp Dev Neurobiol, Nagoya, Aichi 4648602, Japan

[5] Hokkaido Univ, Grad Sch Med, Dept Mol Neuroanat, Sapporo, Hokkaido 0608637, Japan

[6] Univ Tokyo, Inst Med Sci, Dept Basic Med Sci, Div Neuronal Network, Tokyo 1088639, Japan

[7] Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300101, Japan

[8] Kumamoto Univ, Div Cellular Interact, Inst Embryol & Genet, Kumamoto 8600811, Japan

[9] Natl Inst Physiol Sci, Lab Neurobiol & Behav Genet, Okazaki, Aichi 4448585, Japan

[10] Osaka Univ, Grad Sch Frontier Biosci, Labs Integrated Biol, KOKORO Biol Grp, Suita, Osaka 5650871, Japan

[11] SOKENDAI, Dept Genet, Mishima, Shizuoka 4118540, Japan

[12] Univ Paris 06, CNRS, UMR 7102, F-75005 Paris, France

[13] Trinity Coll Dublin, Smufit Inst Genet, Dublin 2, Ireland

来源：

NEURON | 2007年 / 53卷 / 04期

基金：

爱尔兰科学基金会; 日本科学技术振兴机构;

关键词：

D O I：

10.1016/j.neuron.2007.01.028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hippocampal mossy fibers project preferentially to the stratum lucidum, the proximal-most lamina of the suprapyramidal region of CA3. The molecular mechanisms that govern this lamina-restricted projection are still unknown. We examined the projection pattern of mossy fibers in mutant mice for semaphorin receptors plexin-A2 and plexin-A4, and their ligand, the transmembrane semaphorin Sema6A. We found that plexin-A2 deficiency causes a shift of mossy fibers from the suprapyramidal region to the infra- and intrapyramidal regions, while plexin-A4 deficiency induces inappropriate spreading of mossy fibers within CA3. We also report that the plexin-A2 loss-of-function phenotype is genetically suppressed by Sema-6A loss of function. Based on these results, we propose a model for the lamina-restricted projection of mossy fibers: the expression of plexinA4 on mossy fibers prevents them from entering the Sema6A-expressing suprapyramidal region of CA3 and restricts them to the proximal-most part, where Sema6A repulsive activity is attenuated by plexin-A2.

引用

页码：535 / 547

页数：13

共 41 条

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