Singlet oxygen generation via two-photon excited FRET

被引：219

作者：

Dichtel, WR

Serin, JM

Edder, C

Fréchet, JMJ

Matuszewski, M

Tan, LS

Ohulchanskyy, TY

Prasad, PN

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] SUNY Buffalo, Inst Lasers Photon & Biophoton, Buffalo, NY 14260 USA

[3] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

[4] USAF, Res Lab, Polymer Branch, MLBP,Area B, Wright Patterson AFB, OH 45433 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 17期

关键词：

D O I：

10.1021/ja031647x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions. Copyright © 2003 American Chemical Society.

引用

页码：5380 / 5381

页数：2

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