Inherited Predisposition to Gastrointestinal Stromal Tumor

被引：28

作者：

Agarwal, Rinki ^{[1
]}

Robson, Mark ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Clin Genet & Breast Canc Med Serv, Dept Med, New York, NY 10065 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 23卷 / 01期

关键词：

Gastrointestinal stromal tumor; Germline; c-KIT; PDGFRA; Neurofibromatosis; Carney-Stratakis; C-KIT GENE; AUTONOMIC NERVE TUMORS; FACTOR-RECEPTOR-ALPHA; GERMLINE MUTATION; CARNEY TRIAD; FAMILIAL GIST; MOUSE MODEL; EXTRAADRENAL PARAGANGLIOMA; NEUROFIBROMATOSIS TYPE-1; PULMONARY CHONDROMA;

D O I：

10.1016/j.hoc.2008.12.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and are a relatively recently identified category of mesenchymal tumors. Germline mutations in a number of different genes predispose to GIST. This article discusses familial GIST syndrome, Carney triad, Carney-Stratakis syndrome, and neurofibromatosis type 1, and addresses the recognition of an inherited predisposition in GIST patients.

引用

页码：1 / +

页数：14

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