MicroRNAs in the control of metastatic bone disease

被引：63

作者：

Browne, Gillian ^{[1
,2
]}

Taipaleenmaeki, Hanna ^{[3
]}

Stein, Gary S. ^{[1
,2
]}

Stein, Janet L. ^{[1
,2
]}

Lian, Jane B. ^{[1
,2
]}

机构：

[1] Univ Vermont, Coll Med, Vermont Canc Ctr, Burlington, VT 05405 USA

[2] Univ Vermont, Coll Med, Dept Biochem, Burlington, VT 05405 USA

[3] Univ Med Ctr Hamburg Eppendorf, Dept Trauma Hand & Reconstruct Surg, Heisenberg Grp Mol Skeletal Biol, Hamburg, Germany

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2014年 / 25卷 / 06期

基金：

美国国家卫生研究院;

关键词：

breast cancer; prostate cancer; miRNA; bone metastasis; osteolytic/osteoblastic disease; EPITHELIAL-MESENCHYMAL TRANSITION; NONCODING RNA HOTAIR; CANCER STEM-CELLS; BREAST-CANCER; PROSTATE-CANCER; HEMATOPOIETIC STEM; OSTEOCLAST PROGENITORS; CIRCULATING MICRORNAS; SUPPRESSOR-CELLS; REPRESSORS ZEB1;

D O I：

10.1016/j.tem.2014.03.014

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Bone metastasis is a common and devastating complication of late-stage breast and prostate cancer. Complex interactions between tumor cells, bone cells, and a milieu of components in their microenvironment contribute to the osteolytic, osteoblastic, or mixed lesions present in patients with metastasis to bone. In the past decade microRNAs (miRNAs) have emerged as key players in cancer progression, but the importance of miRNAs in regulating cancer metastasis to bone is only now being appreciated. We emphasize here important concepts of bone biology and miRNAs in the context of breast and prostate cancer, and focus on recent advances that have improved our understanding of the role of specific miRNAs with direct involvement in metastatic bone disease.

引用

收藏

页码：320 / 327

页数：8

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