Sugar-Sweetened Beverage Intake and Cancer Recurrence and Survival in CALGB 89803 (Alliance)

被引：64

作者：

Fuchs, Michael A. ^{[1
]}

Sato, Kaori ^{[2
]}

Niedzwiecki, Donna ^{[3
]}

Ye, Xing ^{[3
]}

Saltz, Leonard B. ^{[4
]}

Mayer, Robert J. ^{[2
]}

Mowat, Rex B. ^{[5
]}

Whittom, Renaud ^{[6
]}

Hantel, Alexander ^{[7
]}

Benson, Al ^{[8
]}

Atienza, Daniel ^{[9
]}

Messino, Michael ^{[10
]}

Kindler, Hedy ^{[11
]}

Venook, Alan ^{[12
]}

Ogino, Shuji ^{[2
,13
]}

Wu, Kana ^{[14
]}

Willett, Walter C. ^{[14
,15
]}

Giovannucci, Edward L. ^{[15
,16
,17
]}

Meyerhardt, Jeffrey A. ^{[2
]}

机构：

[1] Brown Univ, Providence, RI 02912 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Duke Univ, Med Ctr, Alliance Stat & Data Ctr, Durham, NC USA

[4] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[5] Toledo Community Hosp, Oncol Program, Toledo, OH USA

[6] Hop Sacre Coeur, Montreal, PQ H4J 1C5, Canada

[7] Loyola Univ, Stritch Sch Med, Naperville, IL USA

[8] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[9] Virginia Oncol Associates, Norfolk, VA USA

[10] Mission Hosp Inc, Southeast Canc Control Consortium, Asheville, NC USA

[11] Univ Chicago, Chicago, IL 60637 USA

[12] Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA 94143 USA

[13] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[14] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[15] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[16] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[17] Harvard Univ, Sch Med, Boston, MA USA

来源：

PLOS ONE | 2014年 / 9卷 / 06期

关键词：

III COLON-CANCER; FOOD FREQUENCY QUESTIONNAIRE; DIETARY GLYCEMIC LOAD; GROWTH-FACTOR-I; COLORECTAL-CANCER; BODY-WEIGHT; EPIDEMIOLOGIC EVIDENCE; PHYSICAL-ACTIVITY; CELL-LINE; C-PEPTIDE;

D O I：

10.1371/journal.pone.0099816

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown. Methods: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models. Results: Patients consuming >= 2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming <2 servings per month (P-trend = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index >= 25 kg/m(2)) and less physically active (metabolic equivalent task-hours per week < 18) (HR = 2.22; 95% CI, 1.29-3.81, P-trend = 0.0025). Conclusion: Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.

引用

页数：9

共 48 条

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