Stimulation of neural cells by lateral layer-by-layer films of single-walled currents in conductive carbon nanotubes

被引:109
作者
Gheith, Mithammed K.
Pappas, Todd C.
Liopo, Anton V.
Sinani, Vladimir A.
Shim, Bong Sup
Motamedi, Massoud
Wicksted, James R.
Kotov, Nicholas A.
机构
[1] Univ Michigan, Dept Chem Engn, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[2] Oklahoma State Univ, Dept Phys, Stillwater, OK 74078 USA
[3] Univ Texas, Med Branch, Ctr Biomed Engn, Galveston, TX 77555 USA
关键词
D O I
10.1002/adma.200600878
中图分类号
O6 [化学];
学科分类号
0703 [化学];
摘要
The first example of neural stimulation through a SWNT material assembled by layer-by-layer deposition is described (see figure). Excitation by lateral currents in the nanotube coating results in the opening of voltage -dependent Na' ion channels. The experimental observations indicate the possibility of engineering of implantable biomedical devices from SWNT/polymer multilayers to be used for neuron prosthesis, pain management, and muscle stimulation.
引用
收藏
页码:2975 / +
页数:6
相关论文
共 50 条
[1]
Regulation of stimulatory adenylyl cyclase signaling during forskolin-induced differentiation of mouse neuroblastoma x rat glioma (NG1O8-15) cells [J].
Ammer, H ;
Schulz, R .
NEUROSCIENCE LETTERS, 1997, 230 (03) :143-146
[2]
Near-infrared optical sensors based on single-walled carbon nanotubes [J].
Barone, PW ;
Baik, S ;
Heller, DA ;
Strano, MS .
NATURE MATERIALS, 2005, 4 (01) :86-U16
[3]
Carbon nanotube actuators [J].
Baughman, RH ;
Cui, CX ;
Zakhidov, AA ;
Iqbal, Z ;
Barisci, JN ;
Spinks, GM ;
Wallace, GG ;
Mazzoldi, A ;
De Rossi, D ;
Rinzler, AG ;
Jaschinski, O ;
Roth, S ;
Kertesz, M .
SCIENCE, 1999, 284 (5418) :1340-1344
[4]
Enzyme-coated carbon nanotubes as single-molecule biosensors [J].
Besteman, K ;
Lee, JO ;
Wiertz, FGM ;
Heering, HA ;
Dekker, C .
NANO LETTERS, 2003, 3 (06) :727-730
[5]
Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties [J].
Bianco, A ;
Hoebeke, J ;
Godefroy, S ;
Chaloin, O ;
Pantarotto, D ;
Briand, JP ;
Muller, S ;
Prato, M ;
Partidos, CD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (01) :58-59
[6]
ELECTROCHEMICAL ASPECTS OF DC STIMULATION OF OSTEOGENESIS [J].
BLACK, J ;
BARANOWSKI, TJ ;
BRIGHTON, CT .
BIOELECTROCHEMISTRY AND BIOENERGETICS, 1984, 12 (3-4) :323-327
[7]
Charge transfer from adsorbed proteins [J].
Bradley, K ;
Briman, M ;
Star, A ;
Gruner, G .
NANO LETTERS, 2004, 4 (02) :253-256
[8]
Fast voltage transients in capacitive silicon-to-cell stimulation detected with a luminescent molecular electronic probe [J].
Braun, D ;
Fromherz, P .
PHYSICAL REVIEW LETTERS, 2001, 86 (13) :2905-2908
[9]
Physiological patterns of electrical stimulation can induce neuronal gene expression by activating N-type calcium channels [J].
Brosenitsch, TA ;
Katz, DM .
JOURNAL OF NEUROSCIENCE, 2001, 21 (08) :2571-2579
[10]
An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices [J].
Chen, RJ ;
Choi, HC ;
Bangsaruntip, S ;
Yenilmez, E ;
Tang, XW ;
Wang, Q ;
Chang, YL ;
Dai, HJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (05) :1563-1568