Multiple roles for integrins during development

被引：25

作者：

BeauvaisJouneau, A

Thiery, JP

机构：

[1] Subcellular Struct. and Cell. Dynam., UMR 144, Research Division, 75248 Paris Cedex 05, 26, rue d'Ulm

来源：

BIOLOGY OF THE CELL | 1997年 / 89卷 / 01期

关键词：

integrins; extracellular matrix; development; null mutation; opportunistic compensation;

D O I：

10.1016/S0248-4900(99)80076-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interactions between cells and extracellular matrix play a crucial role during development by controlling tissue remodelling and cell migration. Integrins are the main family of cell surface receptors for extracellular matrix. The knockout of integrin genes in mouse embryos has provided new insights into the function of these receptors during embryonic development and morphogenesis. The lethality observed either during embryonic life or after birth suggests that many integrins are essential.

引用

页码：5 / 11

页数：7

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