Epithelium, Cilia, and Mucus: Their Importance in Chronic Rhinosinusitis

被引：97

作者：

Antunes, Marcelo B. ^{[1
]}

Gudis, David A. ^{[1
]}

Cohen, Noam A. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19004 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2009年 / 29卷 / 04期

关键词：

Chronic rhinosinusitis; Mucociliary clearance; Cilia; Mucus; Respiratory epithelium; OUTER DYNEIN ARMS; NASAL MUCOCILIARY CLEARANCE; MAMMALIAN RESPIRATORY-TRACT; BEAT FREQUENCY; CHRONIC SINUSITIS; AIRWAY EPITHELIUM; NITRIC-OXIDE; CELLS; PKA; TRANSPORT;

D O I：

10.1016/j.iac.2009.07.004

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Chronic rhinosinusitis is a common disease resulting from inflammation of the sinonasal mucosa. It has long been recognized that patients with chronic rhinosinusitis have impaired capacity to clear sinonasal secretions. However, the cause of this pathologic process is not well understood. In this article the components of mucociliary clearance, including cilia, mucus production, and cilia beat frequency, are reviewed and alterations of the system discussed regarding contribution to the disease process.

引用

页码：631 / +

页数：14

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