Colchicine intoxication in four elderly patients: How to prevent it?

被引：4

作者：

Le Bellec, M. -L. ^{[1
]}

de la Gastine, B. ^{[1
]}

Mosquet, B. ^{[1
]}

Godde, F. ^{[2
]}

Bekolo, R. Ze ^{[3
]}

Gloro, R. ^{[4
]}

Leterrier, C. ^{[5
]}

Coquerel, A. ^{[1
]}

机构：

[1] CHU Cote Nacre, Ctr Reg Pharmacovigilance, F-14033 Caen 9, France

[2] Ctr Hosp Avranches, Serv Reanimat, F-50300 Avranches, France

[3] CHU Cote Nacre, Serv Malad Infect, F-14033 Caen 9, France

[4] CHU Cote Nacre, Serv Hepatogastroenterol, F-14033 Caen 9, France

[5] Ctr Hosp Bayeux, Serv Med Interne, F-14401 Bayeux, France

来源：

REVUE DE MEDECINE INTERNE | 2009年 / 30卷 / 09期

关键词：

Colchicine; Elderly; Intoxication; Adverse drug events; ACUTE GOUT; MANAGEMENT;

D O I：

10.1016/j.revmed.2009.03.013

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Introduction. - In France, unlike other countries, the use of colchicine is preferred to other anti-inflammatory drugs for the treatment of gout. Case reports. - We report a case series of four elderly patients (range from 72 to 83 years of age) who presented with colchicine intoxication, all notified to the Basse-Normandie pharmacovigilance centre in 2007. For each patient, one or more risk factors were identified: renal failure, high initial dosage, absence of laboratory monitoring. Conclusion. - It would be useful to establish specific guidelines for colchicine use in the elderly population. (C) 2009 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：783 / 788

页数：6

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