Mapping Human Genetic Diversity in Asia

被引：434

作者：

Abdulla, Mahmood Ameen ^{[2
,3
]}

Ahmed, Ikhlak ^{[4
]}

Assawamakin, Anunchai ^{[5
,6
]}

Bhak, Jong ^{[7
]}

Brahmachari, Samir K. ^{[4
]}

Calacal, Gayvelline C. ^{[8
]}

Chaurasia, Amit ^{[4
]}

Chen, Chien-Hsiun ^{[9
]}

Chen, Jieming ^{[10
]}

Chen, Yuan-Tsong ^{[9
]}

Chu, Jiayou ^{[11
]}

Cutiongco-de la Paz, Eva Maria C. ^{[12
]}

De Ungria, Maria Corazon A. ^{[8
]}

Delfin, Frederick C. ^{[8
]}

Edo, Juli ^{[2
,3
]}

Fuchareon, Suthat ^{[5
]}

Ghang, Ho ^{[7
]}

Gojobori, Takashi ^{[13
,14
,15
]}

Han, Junsong ^{[16
]}

Ho, Sheng-Feng ^{[9
]}

Hoh, Boon Peng ^{[17
]}

Huang, Wei ^{[18
]}

Inoko, Hidetoshi ^{[19
]}

Jha, Pankaj ^{[4
]}

Jinam, Timothy A. ^{[2
,3
]}

Jin, Li ^{[1
,20
,40
]}

Jung, Jongsun ^{[21
]}

Kangwanpong, Daoroong ^{[22
]}

Kampuansai, Jatupol ^{[22
]}

Kennedy, Giulia C. ^{[23
,24
]}

Khurana, Preeti ^{[25
]}

Kim, Hyung-Lae ^{[21
]}

Kim, Kwangjoong ^{[21
]}

Kim, Sangsoo ^{[26
]}

Kim, Woo-Yeon ^{[7
]}

Kimm, Kuchan ^{[27
]}

Kimura, Ryosuke ^{[28
]}

Koike, Tomohiro ^{[13
,14
]}

Kulawonganunchai, Supasak ^{[6
]}

Kumar, Vikrant ^{[10
]}

Lai, Poh San ^{[29
,30
]}

Lee, Jong-Young ^{[21
]}

Lee, Sunghoon ^{[7
]}

Liu, Edison T. ^{[10
]}

Majumder, Partha P. ^{[31
]}

Mandapati, Kiran Kumar ^{[25
]}

Marzuki, Sangkot ^{[32
]}

Mitchell, Wayne ^{[33
,34
]}

Mukerji, Mitali ^{[4
]}

Naritomi, Kenji ^{[35
]}

机构：

[1] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[2] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Fac Arts & Social Sci, Dept Anthropol, Kuala Lumpur 50603, Malaysia

[4] CSIR, Inst Genom & Integrat Biol, Delhi 110007, India

[5] Mahidol Univ, Puttamonthon 73170, Nakornpathom, Thailand

[6] Natl Ctr Genet Engn & Biotechnol, Genome Inst, Biostat & Informat Lab, Pathum Thani 12120, Thailand

[7] KRIBB, KOBIC, Taejon 305806, South Korea

[8] Univ Philippines, Nat Sci Res Inst, DNA Anal Lab, Quezon City 1101, Philippines

[9] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

[10] Genome Inst Singapore, Singapore 138672, Singapore

[11] Chinese Acad Med Sci, Inst Med Biol, Kunming, Peoples R China

[12] Univ Philippines Manila, Natl Inst Hlth, Inst Human Genet, Ermita Manila 1000, Philippines

[13] Res Org Informat & Syst, Ctr Informat Biol, Mishima, Shizuoka 4118540, Japan

[14] Res Org Informat & Syst, DNA Data Bank Japan, Natl Inst Genet, Mishima, Shizuoka 4118540, Japan

[15] Natl Inst Adv Ind Sci & Technol, Biomed Informat Res Ctr, Koto Ku, Tokyo 1350064, Japan

[16] Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China

[17] Univ Sains Malaysia, Sch Med Sci, Ctr Human Genome, Kubang Kerian 16150, Kelantan, Malaysia

[18] Chinese Natl Human Genome Ctr Shanghai, MOST Shanghai Lab Dis & Hlth Genom, Shanghai 201203, Peoples R China

[19] Tokai Univ, Sch Med, Dept Mol Life Sci, Div Mol Med Sci & Mol Med, Isehara, Kanagawa A2591193, Japan

[20] Fudan Univ, Sch Life Sci, MOE Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China

[21] Korea Natl Inst Hlth, Seoul 122701, South Korea

[22] Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50202, Thailand

[23] Affymetrix, Genom Collaborat, Santa Clara, CA 95051 USA

[24] Veracyte, San Francisco, CA 94080 USA

[25] Ctr Genom Applicat, New Delhi 110020, India

[26] Soongsil Univ, Seoul 156743, South Korea

[27] Eulji Univ, Coll Med, Taejon 301832, South Korea

[28] Univ Tokyo, Grad Sch Med, Dept Human Genet, Bunkyo Ku, Tokyo 1130033, Japan

[29] Natl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Paediat, Singapore 119074, Singapore

[30] DSO Natl Labs, Def Med & Environm Res Inst, Populat Genet Lab, Singapore 117510, Singapore

[31] Indian Stat Inst, Kolkata 700108, India

[32] Eijkman Inst Mol Biol, Jakarta 10430, Indonesia

[33] Informat Expt Therapeut Ctr, Singapore 138669, Singapore

[34] Nanyang Technol Univ, Sch Comp Engn, Div Informat Sci, Singapore 639798, Singapore

[35] Univ Ryukyus, Fac Med, Dept Med Genet, Okinawa 9030215, Japan

[36] Natl Sci & Technol Dev Agcy, Pathum Thani 12120, Thailand

[37] Monash Univ, Bandar Sunway 46150, Selangor, Malaysia

[38] RIKEN, Genom Sci Ctr, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[39] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Lab Funct Genom,Shirokanedai Lab,Minato Ku, Tokyo 1088639, Japan

[40] Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Soc, Partner Inst Computat Biol, Shanghai 200031, Peoples R China

[41] NIMH, Genom Res Branch, NIH, Bethesda, MD 20892 USA

[42] Hlth Sci Univ Hokkaido, Res Inst Personalized Hlth Sci, Tobetsu 0610293, Japan

来源：

SCIENCE | 2009年 / 326卷 / 5959期

关键词：

POPULATION-STRUCTURE; WIDE ANALYSIS; ADMIXTURE; GEOGRAPHY; UYGHURS; HISTORY; EUROPE;

D O I：

10.1126/science.1177074

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

引用

页码：1541 / 1545

页数：5

共 26 条

[1]

Brahmachari SK, 2008, J GENET, V87, P3

[2] The application of molecular genetic approaches to the study of human evolution [J].

Cavalli-Sforza, LL ;

Feldman, MW .

NATURE GENETICS, 2003, 33 :266-275

[3]

Cavalli-Sforza LL, 1993, HIST GEOGRAPHY HUMAN

[4] Genetic relationship of populations in China [J].

Chu, JY ;

Huang, W ;

Kuang, SQ ;

Wang, JM ;

Xu, JJ ;

Chu, ZT ;

Yang, ZQ ;

Lin, KQ ;

Li, P ;

Wu, M ;

Geng, ZC ;

Tan, CC ;

Du, RF ;

Jin, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) :11763-11768

[5]

Telles MPD, 2005, GENET MOL RES, V4, P742

[6] Population structure and history in East Asia [J].

Ding, YC ;

Wooding, S ;

Harpending, HC ;

Chi, HC ;

Li, HP ;

Fu, YX ;

Pang, JF ;

Yao, YG ;

Yu, JGX ;

Moyzis, R ;

Zhang, YP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (25) :14003-14006

[7] The International HapMap Project [J].

Gibbs, RA ;

Belmont, JW ;

Hardenbol, P ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Ch'ang, LY ;

Huang, W ;

Liu, B ;

Shen, Y ;

Tam, PKH ;

Tsui, LC ;

Waye, MMY ;

Wong, JTF ;

Zeng, CQ ;

Zhang, QR ;

Chee, MS ;

Galver, LM ;

Kruglyak, S ;

Murray, SS ;

Oliphant, AR ;

Montpetit, A ;

Hudson, TJ ;

Chagnon, F ;

Ferretti, V ;

Leboeuf, M ;

Phillips, MS ;

Verner, A ;

Kwok, PY ;

Duan, SH ;

Lind, DL ;

Miller, RD ;

Rice, JP ;

Saccone, NL ;

Taillon-Miller, P ;

Xiao, M ;

Nakamura, Y ;

Sekine, A ;

Sorimachi, K ;

Tanaka, T ;

Tanaka, Y ;

Tsunoda, T ;

Yoshino, E ;

Bentley, DR ;

Deloukas, P ;

Hunt, S ;

Powell, D ;

Altshuler, D ;

Gabriel, SB ;

Qiu, RZ .

NATURE, 2003, 426 (6968) :789-796

[8] Inferring human colonization history using a copying model [J].

Hellenthal, Garrett ;

Auton, Adam ;

Falush, Daniel .

PLOS GENETICS, 2008, 4 (05)

[9] Genorne-wide analysis indicates more Asian than melanesian ancestry of polynesians [J].

Kayser, Manfred ;

Lao, Oscar ;

Saar, Kathrin ;

Brauer, Silke ;

Wang, Xingyu ;

Nuernberg, Peter ;

Trent, Ronald J. ;

Stoneking, Mark .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (01) :194-198

[10] Correlation between genetic and geographic structure in Europe [J].

Lao, Oscar ;

Lu, Timothy T. ;

Nothnagel, Michael ;

Junge, Olaf ;

Freitag-Wolf, Sandra ;

Caliebe, Amke ;

Balascakova, Miroslava ;

Bertranpetit, Jaume ;

Bindoff, Laurence A. ;

Comas, David ;

Hoimlund, Gunilla ;

Kouvatsi, Anastasia ;

Macek, Milan ;

Mollet, Isabelle ;

Parson, Walther ;

Palo, Jukka ;

Ploski, Rafal ;

Sajantila, Antti ;

Tagliabracci, Adriano ;

Gether, Ulrik ;

Werge, Thomas ;

Rivadeneira, Fernando ;

Hofman, Albert ;

Uitterlinden, Andre G. ;

Gieger, Christian ;

Wichmann, Heinz-Erich ;

Ruether, Andreas ;

Schreiber, Stefan ;

Becker, Christian ;

Nuernberg, Peter ;

Nelson, Matthew R. ;

Krawczak, Michael ;

Kayser, Manfred .

CURRENT BIOLOGY, 2008, 18 (16) :1241-1248

← 1 2 3 →