Trekking across the brain: The journey of neuronal migration

被引：477

作者：

Ayala, Ramses ^{[1
]}

Shu, Tianzhi ^{[1
]}

Tsai, Li-Huei ^{[1
]}

机构：

[1] MIT, Howard Hughes Med Inst, Picower Inst Learning & Memory, Dept Brain & Cognit Sci,RIKEN,Neurosci Res Ctr, Cambridge, MA 02139 USA

来源：

CELL | 2007年 / 128卷 / 01期

关键词：

D O I：

10.1016/j.cell.2006.12.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The correct positioning of neurons during development -achieved through directed migration-is the basis for proper brain function. Several decades of research have yielded a comprehensive map illustrating the temporal and spatial events underlying neurogenesis and neuronal migration during development. The discovery of distinct migration modes and pathways has been accompanied by the identification of a large interwoven molecular network that transmits extracellular signals into the cell. Moreover, recent work has shed new light on how the cytoskeleton is regulated and coordinated at the molecular and cellular level to execute neuronal migration.

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收藏

页码：29 / 43

页数：15

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