Cellular mechanisms of insulin resistance

被引：1664

作者：

Shulman, GI

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Internal Med, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2000年 / 106卷 / 02期

关键词：

D O I：

10.1172/JCI10583

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

引用

页码：171 / 176

页数：6

共 45 条

[1]

MECHANISMS OF FATTY ACID-INDUCED INHIBITION OF GLUCOSE-UPTAKE [J].

BODEN, G ;

CHEN, XH ;

RUIZ, J ;

WHITE, JV ;

ROSSETTI, L .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (06) :2438-2446

[2]

CORRELATION BETWEEN MUSCLE GLYCOGEN-SYNTHASE ACTIVITY AND INVIVO INSULIN ACTION IN MAN [J].

BOGARDUS, C ;

LILLIOJA, S ;

STONE, K ;

MOTT, D .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (04) :1185-1190

[3]

Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM [J].

Bonadonna, RC ;

DelPrato, S ;

Bonora, E ;

Saccomani, MP ;

Gulli, G ;

Natali, A ;

Frascerra, S ;

Pecori, N ;

Ferrannini, E ;

Bier, D ;

Cobelli, DBC ;

DeFronzo, RA .

DIABETES, 1996, 45 (07) :915-925

[4]

REDUCED EXPRESSION OF HEXOKINASE-II IN INSULIN-RESISTANT DIABETES [J].

BRAITHWAITE, SS ;

PALAZUK, B ;

COLCA, JR ;

EDWARDS, CW ;

HOFMANN, C .

DIABETES, 1995, 44 (01) :43-48

[5]

Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat [J].

Chalkley, SM ;

Hettiarachchi, M ;

Chisholm, DJ ;

Kraegen, EW .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (09) :1121-1126

[6]

Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes [J].

Cline, GW ;

Petersen, KF ;

Krssak, M ;

Shen, J ;

Hundal, RS ;

Trajanoski, Z ;

Inzucchi, S ;

Dresner, A ;

Rothman, DL ;

Shulman, GI .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (04) :240-246

[7]

REDUCED GLYCOGEN-SYNTHASE ACTIVITY IN SKELETAL-MUSCLE FROM OBESE PATIENTS WITH AND WITHOUT TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS [J].

DAMSBO, P ;

VAAG, A ;

HOTHERNIELSEN, O ;

BECKNIELSEN, H .

DIABETOLOGIA, 1991, 34 (04) :239-245

[8]

THE TRIUMVIRATE - BETA-CELL, MUSCLE, LIVER - A COLLUSION RESPONSIBLE FOR NIDDM [J].

DEFRONZO, RA .

DIABETES, 1988, 37 (06) :667-687

[9]

AN INVITRO HUMAN MUSCLE PREPARATION SUITABLE FOR METABOLIC STUDIES - DECREASED INSULIN STIMULATION OF GLUCOSE-TRANSPORT IN MUSCLE FROM MORBIDLY OBESE AND DIABETIC SUBJECTS [J].

DOHM, GL ;

TAPSCOTT, EB ;

PORIES, WJ ;

DABBS, DJ ;

FLICKINGER, EG ;

MEELHEIM, D ;

FUSHIKI, T ;

ATKINSON, SM ;

ELTON, CW ;

CARO, JF .

JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (02) :486-494

[10]

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity [J].

Dresner, A ;

Laurent, D ;

Marcucci, M ;

Griffin, ME ;

Dufour, S ;

Cline, GW ;

Slezak, LA ;

Andersen, DK ;

Hundal, RS ;

Rothman, DL ;

Petersen, KF ;

Shulman, GI .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :253-259

← 1 2 3 4 5 →