Stereochemical implications on diversity in β-turn peptidomimetic libraries

被引：20

作者：

Feng, YB ^{[1
]}

Pattarawarapan, M ^{[1
]}

Wang, ZC ^{[1
]}

Burgess, K ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 25期

关键词：

D O I：

10.1021/jo991150z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoisomers of compound 1 were prepared, and their preferred solution-phase conformations (in DMSO) were determined by a combination of NMR, CD, and molecular simulation approaches. It was shown that the stereochemistry of the pseudo i + 2 residue is the predominant consideration.

引用

页码：9175 / 9177

页数：3

共 15 条

[1] Solution structure and internal motion of a bioactive peptide derived from nerve growth factor
Beglova, N
LeSauteur, L
Ekiel, I
Saragovi, HU
Gehring, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (37) : 23652 - 23658
[2] HYDROGEN-EXCHANGE
ENGLANDER, SW
DOWNER, NW
TEITELBAUM, H
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1972, 41 : 903 - +
[3] FENG Y, 1999, IN PRESS CHEM EUR J
[4] SNAr cyclizations to form cyclic peptidomimetics of β-turns
Feng, YB
Wang, ZC
Jin, S
Burgess, K
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (41) : 10768 - 10769
[5] NERVE GROWTH-FACTOR IN DIFFERENT CRYSTAL FORMS DISPLAYS STRUCTURAL FLEXIBILITY AND REVEALS ZINC-BINDING SITES
HOLLAND, DR
COUSENS, LS
MENG, W
MATTHEWS, BW
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 239 (03) : 385 - 400
[6] CONFORMATIONS OF CYCLIC PEPTIDES .3. CYCLOPENTAGLYCYLTYROSYL AND RELATED COMPOUNDS
KOPPLE, KD
OHNISHI, M
GO, A
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1969, 91 (15) : 4264 - +
[7] SMALL PEPTIDE MIMICS OF NERVE GROWTH-FACTOR BIND TRKA RECEPTORS AND AFFECT BIOLOGICAL RESPONSES
LESAUTEUR, L
WEI, L
GIBBS, BF
SARAGOVI, HU
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (12) : 6564 - 6569
[8] MEASURING DIVERSITY - EXPERIMENTAL-DESIGN OF COMBINATORIAL LIBRARIES FOR DRUG DISCOVERY
MARTIN, EJ
BLANEY, JM
SIANI, MA
SPELLMEYER, DC
WONG, AK
MOOS, WH
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (09) : 1431 - 1436
[9] NEW-PROTEIN FOLD REVEALED BY A 2.3-A RESOLUTION CRYSTAL-STRUCTURE OF NERVE GROWTH-FACTOR
MCDONALD, NQ
LAPATTO, R
MURRAYRUST, J
GUNNING, J
WLODAWER, A
BLUNDELL, TL
[J]. NATURE, 1991, 354 (6352) : 411 - 414
[10] QUENCHED MOLECULAR-DYNAMICS SIMULATIONS OF TUFTSIN AND PROPOSED CYCLIC ANALOGS
OCONNOR, SD
SMITH, PE
ALOBEIDI, F
PETTITT, BM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (15) : 2870 - 2881

← 1 2 →