Simple preparation of optically pure bis(trifluoromethyl)-alkanediols through lipase-catalyzed reaction

被引：13

作者：

Itoh, T

Shiromoto, M

Inoue, H

Hamada, H

Nakamura, K

机构：

[1] OKAYAMA UNIV SCI,DEPT APPL SCI,OKAYAMA 700,JAPAN

[2] KYOTO UNIV,INST CHEM RES,UJI,KYOTO 611,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 28期

关键词：

D O I：

10.1016/0040-4039(96)00994-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective hydrolysis of diacetate of bis(trifluoromethyl)alkanediols has been demonstrated. Candida antarctica lipase was chosen from among commercial enzymes as the one most able to enantioselectively hydrolyze the acetyl group giving optically pure diols and diacetate. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5001 / 5002

页数：2

共 7 条

[1]

CLARK CA, 1980, SPRINGER SER CHEM PH, V11, P222

[2]

FUKUDA A, 1992, FUTURE LIQUID CRYSTA

[3]

GONG PV, 1995, J ORG CHEM, V60, P41

[4] Efficient synthesis of optically pure 1,1,1-trifluoro-2-alkanols through lipase-catalyzed acylation in organic media [J].