Stereospecific and stereodivergent construction of quaternary carbon centers through switchable directed/nondirected allylic substitution

被引：77

作者：

Breit, B ^{[1
]}

Demel, P ^{[1
]}

Studte, C ^{[1
]}

机构：

[1] Univ Freiburg, Inst Organ Chem & Biochem, D-79104 Freiburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 29期

关键词：

allylation; asymmetric synthesis; enantioselectivity; Grignard reaction; organocopper reagents;

D O I：

10.1002/anie.200453991

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Selectivity at the flick of a switch: Through 1,3-chirality transfer, a directing/nondirecting leaving group facilitates the stereospecific and stereodivergent construction of quaternary carbon centers by copper-mediated allylic substitution with Grignard and organozinc reagents (see scheme; the use of the corresponding phosphane oxide leads to selective anti substitution).

引用

页码：3786 / 3789

页数：4

共 34 条

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