Polyoxygenated sterols from the formosan soft coral Sinularia gibberosa

被引：53

作者：

Ahmed, Atallah F.

Hsieh, Ya-Ting

Wen, Zhi-Hong

Wu, Yang-Chang

Sheu, Jyh-Horng ^{[1
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

[3] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 09期

关键词：

D O I：

10.1021/np0601509

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation on the dichloromethane-soluble fraction from the EtOH extract of Sinularia gibberosa Tixier-Durivault has led to the isolation of three new polyoxygenated sterols, gibberoketosterols B ( 1) and C ( 2) and gibberoepoxysterol ( 3), along with two known steroids, gibberoketosterol ( 4) and 24-methylenecholest-5-en-3 beta-ol ( 5). These cholestane-type sterols possessing a 22,24( 28)-conjugated diene ( 1 and 2) in the side chain or a 5 alpha, 6 alpha-epoxide in the B-ring ( 3) were isolated for the first time from marine sources. Compound 4 showed significant inhibition against the up-regulation of the pro-inflammatory iNOS and COX-2 proteins of LPS-stimulated RAW264.7 macrophage cells, while 1 was found to be inactive. The cytotoxicity of 1-4 toward a limited panel of cancer cell lines is also reported.

引用

页码：1275 / 1279

页数：5

共 19 条

[1] 1α,3β,5β-Trihydroxy-24-methylenecholestan-6-one:: a novel steroid from a soft coral Sinularia gibberosa [J].