Successful empirical erlotinib treatment of a mechanically ventilated patient newly diagnosed with metastatic lung adenocarcinoma

被引：20

作者：

Bosch-Barrera, Joaquim ^{[1
,2
,3
]}

Sais, Elia ^{[1
]}

Lorencio, Carol ^{[4
]}

Porta, Rut ^{[1
,2
,3
]}

Izquierdo, Angel ^{[1
,2
]}

Menendez, Javier A. ^{[2
,5
]}

Brunet, Joan ^{[1
,2
,3
]}

Sirvent, Josep Maria ^{[4
]}

Rosell, Rafael ^{[6
]}

机构：

[1] Doctor Josep Trueta Univ Hosp, Catalan Inst Oncol, Dept Med Oncol, Girona 17007, Spain

[2] Girona Biomed Res Inst IDIBGi, Girona, Spain

[3] Univ Girona, Sch Med, Dept Med Sci, Girona, Spain

[4] Doctor Josep Trueta Univ Hosp, Intens Care Unit, Girona, Spain

[5] Catalan Inst Oncol, Translat Res Lab, Girona, Spain

[6] Hosp Badalona Germans Trias & Pujol, Catalan Inst Oncol, Dept Med Oncol, Badalona, Spain

来源：

LUNG CANCER | 2014年 / 86卷 / 01期

关键词：

Non-small-cell lung cancer; Erlotinib; Nasogastric tube; EGFR mutation; Critically ill patient; Intensive care unit; Mechanical ventilation; GROWTH-FACTOR RECEPTOR; INTENSIVE-CARE; 1ST-LINE TREATMENT; OPEN-LABEL; ACTIVATING MUTATIONS; PROGNOSTIC-FACTORS; PHASE-III; CANCER; GEFITINIB; SURVIVAL;

D O I：

10.1016/j.lungcan.2014.07.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Background: Lung cancer is the most common solid tumor in critically ill cancer patients who are admitted to intensive care units (ICUs). An ICU trial consists of unlimited ICU support for a limited time period. Case report: We present the case of a 60-year-old woman with newly diagnosed metastatic lung adenocarcinoma who required mechanical ventilation due to respiratory failure. Empirical erlotinib treatment was administered through a nasogastric feeding tube as part of an ICU trial, which led to a dramatic and durable response. Conclusion: Empirical erlotinib should be considered when epidermal growth factor receptor (EGFR) mutations are suspected in ICU newly diagnosed patients with lung adenocarcinoma. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：102 / 104

页数：3

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