Long-term sequestration of fluorinated compounds in tissues after fluvoxamine or fluoxetine treatment:: a fluorine magnetic resonance spectroscopy study in vivo

被引：28

作者：

Bolo, NR ^{[1
]}

Hodé, Y ^{[1
]}

Macher, JP ^{[1
]}

机构：

[1] FORENAP, Ctr Res Neurosci & Psychiat, Magnet Resonance Unit, F-68250 Rouffach, France

来源：

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE | 2004年 / 16卷 / 06期

关键词：

human pharmacology; SSRI pharmacokinetics; psychotropic drug distribution;

D O I：

10.1007/s10334-004-0033-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Fluorine magnetic resonance spectroscopy (F-19 MRS), spectroscopic imaging (MRSI) and proton anatomical magnetic resonance imaging (H-1 MRI) were performed on brains and lower extremities of six subjects in vivo concurrently with HPLC of serum to investigate tissue and plasma drug localization and withdrawal kinetics in humans treated with fluvoxamine or fluoxetine. F-19 MRS signal was unexpectedly detected in the lower extremities months after complete disappearance of signal from plasma and brain. MRSI suggested that the lower extremity fluvoxamine signal originated mainly from bone marrow. Results suggest long-term sequestration of these drugs or their metabolites mainly in bone marrow and possibly in surrounding tissue and demonstrate the usefulness of MRS to reveal drug-trapping compartments in the body.

引用

页码：268 / 276

页数：9

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