Feeding hungry stem cells

被引:6
作者
Pedersen, RA [1 ]
机构
[1] Univ Cambridge, Addenbrookes Hosp, Dept Surg, Cambridge CB2 2QQ, England
关键词
D O I
10.1038/nbt0902-882
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Growing human embryonic stem cells in an environment free of mouse feeder cells lowers the risk of cross-species infection but does little to clarify what makes stem cells tick..
引用
收藏
页码:882 / 883
页数:2
相关论文
共 11 条
[1]   Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture [J].
Amit, M ;
Carpenter, MK ;
Inokuma, MS ;
Chiu, CP ;
Harris, CP ;
Waknitz, MA ;
Itskovitz-Eldor, J ;
Thomson, JA .
DEVELOPMENTAL BIOLOGY, 2000, 227 (02) :271-278
[2]   Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells [J].
Burdon, T ;
Stracey, C ;
Chambers, I ;
Nichols, J ;
Smith, A .
DEVELOPMENTAL BIOLOGY, 1999, 210 (01) :30-43
[3]  
Cibelli J.B., 2001, J REGEN MED, V2, P25, DOI [10.1089/152489001753262168, DOI 10.1089/152489001753262168]
[4]   The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation - Involvement of STAT3 [J].
Ernst, M ;
Novak, U ;
Nicholson, SE ;
Layton, JE ;
Dunn, AR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (14) :9729-9737
[5]   Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation [J].
Li, S ;
Harrison, D ;
Carbonetto, S ;
Fässler, R ;
Smyth, N ;
Edgar, D ;
Yurchenco, PD .
JOURNAL OF CELL BIOLOGY, 2002, 157 (07) :1279-1290
[6]   Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3 [J].
Niwa, H ;
Burdon, T ;
Chambers, I ;
Smith, A .
GENES & DEVELOPMENT, 1998, 12 (13) :2048-2060
[7]   Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro [J].
Reubinoff, BE ;
Pera, MF ;
Fong, CY ;
Trounson, A ;
Bongso, A .
NATURE BIOTECHNOLOGY, 2000, 18 (04) :399-404
[8]   Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells [J].
Richards, M ;
Fong, CY ;
Chan, WK ;
Wong, PC ;
Bongso, A .
NATURE BIOTECHNOLOGY, 2002, 20 (09) :933-936
[9]   Embryonic stem cell lines derived from human blastocysts [J].
Thomson, JA ;
Itskovitz-Eldor, J ;
Shapiro, SS ;
Waknitz, MA ;
Swiergiel, JJ ;
Marshall, VS ;
Jones, JM .
SCIENCE, 1998, 282 (5391) :1145-1147
[10]  
*US NIH, NIH HUM EMBR STEM CE