Convergence between bone and energy homeostases: Leptin regulation of bone mass

被引：314

作者：

Karsenty, Gerard ^{[1
]}

机构：

[1] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA

来源：

CELL METABOLISM | 2006年 / 4卷 / 05期

关键词：

D O I：

10.1016/j.cmet.2006.10.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The observation that obesity protects from osteoporosis suggested that energy metabolism and bone mass could be regulated by the same hormones. Testing this hypothesis revealed that leptin regulates bone mass through a hypothalamic relay and using two neural mediators, the sympathetic tone and CART, both acting on one cell type the osteoblast. This review summarizes the genetic and molecular bases of this regulation and discusses its potential clinical implications.

引用

页码：341 / 348

页数：8

共 50 条

[1] Body fat, leptin, and hypothalamic amenorrhea [J].

Ahima, RS .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (10) :959-962

[2] Leptin regulation of neuroendocrine systems [J].

Ahima, RS ;

Saper, CB ;

Flier, JS ;

Elmquist, JK .

FRONTIERS IN NEUROENDOCRINOLOGY, 2000, 21 (03) :263-307

[3]

AHN JD, 2006, IN PRESS ENDOCRINOLO

[4] Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet [J].

Asnicar, MA ;

Smith, DP ;

Yang, DD ;

Heiman, ML ;

Fox, N ;

Chen, YF ;

Hsiung, HM ;

Köster, A .

ENDOCRINOLOGY, 2001, 142 (10) :4394-4400

[5]

Bray GA, 1998, RECENT PROG HORM RES, V53, P95

[6] Targeted disruption of the β2 adrenergic receptor gene [J].

Chruscinski, AJ ;

Rohrer, DK ;

Schauble, E ;

Desai, KH ;

Bernstein, D ;

Kobilka, BK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (24) :16694-16700

[7]

Cooper Cyrus, 1996, P419

[8] Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo [J].

Cornish, J ;

Callon, KE ;

Bava, U ;

Lin, C ;

Naot, D ;

Hill, BL ;

Grey, AB ;

Broom, N ;

Myers, DE ;

Nicholson, GC ;

Reid, IR .

JOURNAL OF ENDOCRINOLOGY, 2002, 175 (02) :405-415

[9] Dissociation between bone resorption and bone formation in osteopenic transgenic mice [J].

Corral, DA ;

Amling, M ;

Priemel, M ;

Loyer, E ;

Fuchs, S ;

Ducy, P ;

Baron, R ;

Karsenty, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) :13835-13840

[10] Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis [J].

Dhillon, H ;

Zigman, JM ;

Ye, CP ;

Lee, CE ;

McGovern, RA ;

Tang, VS ;

Kenny, CD ;

Christiansen, LM ;

White, RD ;

Edelstein, EA ;

Coppari, R ;

Balthasar, N ;

Cowley, MA ;

Chua, S ;

Elmquist, JK ;

Lowelll, BB .

NEURON, 2006, 49 (02) :191-203

← 1 2 3 4 5 →