The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

被引：5

作者：

Bailon, Elvira ^{[1
]}

Roman, Juan ^{[2
]}

Ramis, Isabel ^{[2
]}

Michelena, Pedro ^{[2
]}

Balsa, Dolors ^{[2
]}

Merlos, Manuel ^{[2
]}

Zarzuelo, Antonio ^{[1
]}

Galvez, Julio ^{[1
]}

Comalada, Monica ^{[1
]}

机构：

[1] Univ Granada, Sch Pharm, Dept Pharmacol, CIBEREHD, E-18071 Granada, Spain

[2] Palau Pharma SA, Pharmacol & Toxicol, Barcelona, Spain

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2009年 / 109卷 / 02期

关键词：

inflammatory bowel disease; B lymphocyte; Th2-cytokine; NECROSIS-FACTOR-ALPHA; T-CELLS; LYMPHOCYTES; MUCOSAL; DISEASE;

D O I：

10.1254/jphs.08292SC

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The aim of the present study was to evaluate the inmunomodulatory effects of UR-1505, a new salicylate derivative, on the T helper (Th)2/humoral response produced during dextran sodium sulfate (DSS)-induced rat colitis. In the in vitro studies, UR-1505 (300 mu M) inhibited both the production of interleukin (IL)-10 and IL-5 in concanavalin A (Con A)activated splenocytes and the production of immunoglobulin (Ig) G and IgA by B-lymphocytes. However, in contrast to the in vitro results, the administration of UR-1505 (10 and 30 mg/kg per day) to rats with established DSS-colitis enhanced both IL-10 and IgA production, whereas it inhibited IgG production, thus ameliorating the intestinal inflammation.

引用

页码：315 / 318

页数：4

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