ERM proteins and merlin: Integrators at the cell cortex

被引：1134

作者：

Bretscher, A ^{[1
]}

Edwards, K

Fehon, RG

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

[2] Illinois State Univ, Dept Biol Sci, Normal, IL 61790 USA

[3] Duke Univ, Dept Biol, Dev Cell & Mol Biol Grp, Durham, NC 27708 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm882

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and other plasma-membrane processes, including endocytosis and exocytosis. The ezrin-radixin-moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function.

引用

页码：586 / 599

页数：14

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