Sol-gel coatings for protection and bioactivation of metals used in orthopaedic devices

The aim of this work is the production and characterisation of sol - gel coatings for protection and bioactivation of metals used as standard surgical implant materials, such as stainless steel 316 L ( ASTM F138), Co based alloys ( ASTM F75) and titanium alloy Ti-6Al-4V ( ASTM F67). These films should both prevent degradation of the substrates by wear or corrosion, and bioactivate the material for inducing the formation of a hydroxyapatite ( HA) rich layer onto the material surface, thereby permitting a natural bonding to living tissues. Formation of HA layers can be observed on performing in vitro tests by soaking the material in simulated body solutions. The work describes the development of coatings containing bioactive glass and glass-ceramic particles in hybrid methyl-triethoxysilane (MTES) and tetraethylorthosilicate (TEOS) acidic sol, applied by dip-coating to surgical alloys, AISI 316 L, ASTM F75 and ASTM 67, with the aim of accomplishing both high corrosion resistance of the metal in the body environment and adhesion of the implant to the surrounding tissue. The performance of the coated metal was evaluated in vitro by electrochemical techniques including potentiodynamic polarisation curves and electrochemical impedance spectroscopy, to follow the formation of hydroxyapatite on the surface, as well as the in vitro release of ions by plasma atomic emission spectroscopy (ICP-MS) after up to one year of immersion. In vivo behaviour was evaluated by subcutaneous tests and endomedullar implantation in Hokaido rats to study possible rejection reactions and natural bonding to living tissue.