Attachment and tension in the spindle assembly checkpoint

被引：123

作者：

Zhou, J ^{[1
]}

Yao, J ^{[1
]}

Joshi, HC ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Cell Biol, Atlanta, GA 30322 USA

来源：

JOURNAL OF CELL SCIENCE | 2002年 / 115卷 / 18期

关键词：

spindle assembly checkpoint; mitosis; chromosome; kinetochore; microtubule; attachment; tension;

D O I：

10.1242/jcs.00029

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Faithful transmission of chromosomes during mitosis is ensured by the spindle assembly checkpoint. This molecular safeguard examines whether prerequisites for chromosome segregation have been satisfied and thereby determines whether to execute or to delay chromosome segregation. Only when all the chromosomes are attached by kinetochore microtubules from two opposite spindle poles and proper tension is placed on the paired kinetochores does anaphase take place, allowing the physical splitting of sister chromatids. Recent studies have provided novel insights into the molecular mechanisms through which the spindle assembly checkpoint is regulated by both the attachment of chromosomes to kinetochore microtubules and the tension exerted on kinetochores.

引用

页码：3547 / 3555

页数：9

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