What should the clinician know about the cytochrome P450 system?

被引：3

作者：

Benhamou, JP ^{[1
]}

机构：

[1] Hop Beaujon, F-92118 Clichy, France

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2000年 / 12卷 / 04期

关键词：

cytochrome P450; hepatotoxicity;

D O I：

10.1097/00042737-200012040-00008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The cytochromes P450 are a superfamily of enzymes which catalyse mono-oxidation, thus transforming fat-soluble toxins into water-soluble metabolites which are excreted in urine. Cytochromes P450 are mainly located in the liver, they play a major role in hepatotoxicity. The toxins (or the drugs) can be in part transformed into reactive metabolites which destroy intrahepatocytic proteins (metabolite-related hepatotoxicity) or form an immune complex that induces immune reactions (immune-related hepatotoxicity). (C) 2000 Lippincott Williams & Wilkins.

引用

页码：415 / 417

页数：3

共 6 条

[1] Two cytochromes P450 are major hepatocellular autoantigens in autoimmune polyglandular syndrome type 1 [J].