Commensal bacteria mediated defenses against pathogens

被引：118

作者：

Abt, Michael C. ^{[1
]}

Pamer, Eric G. ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Program Immunol, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Mol Microbiol Core Facil, Lucille Castori Ctr Microbes Inflammat & Canc, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Dept Med, New York, NY 10021 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2014年 / 29卷

关键词：

VANCOMYCIN-RESISTANT ENTEROCOCCI; ENTERICA SEROVAR TYPHIMURIUM; ARYL-HYDROCARBON RECEPTOR; INTESTINAL MICROBIOTA; CLOSTRIDIUM-DIFFICILE; GUT MICROBIOTA; THURICIN CD; COLONIZATION; SALMONELLA; CELLS;

D O I：

10.1016/j.coi.2014.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Commensal bacterial communities residing within the intestinal lumen of mammals have evolved to flourish in this microenvironment. To preserve this niche, commensal bacteria act with the host to prevent colonization by invasive pathogens that induce inflammation and disrupt the intestinal niche commensal bacteria occupy. Thus, it is mutually beneficial to the host and commensal bacteria to inhibit a pathogen's ability to establish an infection. Commensal bacteria express factors that support colonization, maximize nutrient uptake, and produce metabolites that confer a survival advantage over pathogens. Further, commensal bacteria stimulate the host's immune defenses and drive tonic expression of anti-microbial factors. In combination, these mechanisms preserve the niche for commensal bacteria and assist the host in preventing infection.

引用

页码：16 / 22

页数：7

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