The impact of chromium on biological systems.

被引：14

作者：

Ferreira, ADQ ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil

来源：

QUIMICA NOVA | 2002年 / 25卷 / 04期

关键词：

chromium; model compounds; DNA; insulin;

D O I：

10.1590/S0100-40422002000400012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The impact of biological chromium's activity may be beneficial or not. This review presents the most relevant chemical aspects of these "two faces" of chromium by covering first, the efforts toward a clearer understanding of the carcinogenic properties of chromium compounds. The biomimetic chemistry of Cr(V) complexes illustrates the interactions of the intermediates formed by Cr(VI) reduction with DNA or oligonucleotides. The importance of trivalent chromium as an essential element is also emphasized by summarizing the recent results of the investigations on trinuclear chromium complexes as models of the cofactor responsible for the insulin activity, as well as good candidates for new nutritional supplements.

引用

页码：572 / 578

页数：7

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