Exosomes:: endosomal-derived vesicles shipping extracellular messages

被引：1060

作者：

Février, B ^{[1
]}

Raposo, G ^{[1
]}

机构：

[1] Inst Curie, CNRS, UMR 144, Res Sect, F-75005 Paris, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 04期

关键词：

D O I：

10.1016/j.ceb.2004.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Exosomes are membrane vesicles released into the extracellular environment upon exocytic fusion of multivesicular endosomes with the cell surface. They have a particular composition reflecting their origin in endosomes as intraluminal vesicles. In vitro and in vivo studies support the contribution of exosomes to an acellular mode of communication, leading to intercellular transfer of molecules. Exosomes may have regulatory functions in the immune system and their application in cancer immunotherapy is promising. The mechanisms involved in exosome secretion and interaction with target cells are as yet unclear. A better understanding of these mechanisms is also essential to determine the link between exosomes and retroviruses.

引用

页码：415 / 421

页数：7

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