Allopregnanolone modulation of HPA axis function in the adult rat

被引：36

作者：

Biggio, Giovanni ^{[1
,2
,3
]}

Pisu, Maria Giuseppina ^{[3
]}

Biggio, Francesca ^{[1
]}

Serra, Mariangela ^{[1
,2
,3
]}

机构：

[1] Univ Cagliari, Dept Life & Environm Sci, I-09100 Cagliari, Italy

[2] Univ Cagliari, Ctr Excellence Neurobiol Dependence, I-09100 Cagliari, Italy

[3] Neurosci Inst, CNR, I-09100 Cagliari, Italy

来源：

PSYCHOPHARMACOLOGY | 2014年 / 231卷 / 17期

关键词：

Allopregnanolone; Social isolation; Maternal separation; Socially isolated parents offspring; HPA axis; PITUITARY-ADRENAL AXIS; ISOLATION-INDUCED INCREASE; GABA(A) RECEPTOR FUNCTION; SOCIAL-ISOLATION; GENE-EXPRESSION; GLUCOCORTICOID-RECEPTOR; ANTICONVULSANT ACTIVITY; GABAERGIC TRANSMISSION; NEUROSTEROID SYNTHESIS; NEUROACTIVE STEROIDS;

D O I：

10.1007/s00213-014-3521-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

GABAergic neuronal circuits regulate neuroendocrine stress response, and the most potent positive endogenous modulator of GABA(A) receptor function is allopregnanolone. This neurosteroid acts in a nongenomic manner to selectively increase the inhibitory signal meditated by GABA(A) receptors; in addition, it also induces long-lasting changes in the expression of specific GABA(A) receptor subunits in various brain regions, with consequent changes in receptor function. The objective of this review is to summarize our findings on emotional state and stress responsiveness in three animal models in which basal brain concentrations of allopregnanolone differ. It is postulated that individual differences in allopregnanolone levels can influence general resilience. The results showed that there is an apparent correlation between endogenous levels of brain allopregnanolone and basal and stress-stimulated HPA axis activity. The relationship between endogenous brain levels of allopregnanolone and HPA axis activity and function sustains the therapeutic potential of this neurosteroid for the treatment of stress-associated disorders.

引用

页码：3437 / 3444

页数：8

共 68 条

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