Hydroxamic acids as pharmacological agents

被引：239

作者：

Muri, EMF ^{[1
]}

Nieto, MJ ^{[1
]}

Sindelar, RD ^{[1
]}

Williamson, JS ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2002年 / 9卷 / 17期

关键词：

hydroxamic acids; metalloenzyme inhibitors; zinc metalloproteinases; leukotriene A(4) hydrolases; lipoxigenases; cyclooxygenases; peptide deformilases;

D O I：

10.2174/0929867023369402

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A(4) hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.

引用

页码：1631 / 1653

页数：23

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