ATP induces leukemia inhibitory factor mRNA in cultured rat astrocytes

被引：26

作者：

Yamakuni, H ^{[1
]}

Kawaguchi, N ^{[1
]}

Ohtani, Y ^{[1
]}

Nakamura, J ^{[1
]}

Katayama, T ^{[1
]}

Nakagawa, T ^{[1
]}

Minami, M ^{[1
]}

Satoh, M ^{[1
]}

机构：

[1] Kyoto Univ, Fac Pharmaceut Sci, Dept Mol Pharmacol, Kyoto 6068501, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 129卷 / 1-2期

关键词：

leukemia inhibitory factor; cytokine; astrocytes; ATP; UTP; purinoceptor;

D O I：

10.1016/S0165-5728(02)00179-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leukemia inhibitory factor (LIF) is a cytokine involved in the survival and differentiation of the neural cells in the central and peripheral nervous systems. In the present study, we examined the effects of various neurotransmitter receptor agonists on LIF mRNA expression in cultured rat astrocytes, microglia and neurons to elucidate the cell types producing LIF and to clarify, the neurotransmitter(s) regulating the mRNA expression. The results demonstrated that the expression of LIF mRNA was intensely induced by ATP in the cultured astrocytes. Experiments using ATP, UTP and related compounds showed the involvement of P2Y(2) and P2Y(4) purinoceptors in the expression induced by ATP. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：43 / 50

页数：8

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