Synthesis and structure-activity relationships of a new class of selective EP3 receptor agonist, 13,14-didehydro-16-phenoxy analogues of prostaglandin E1

被引：12

作者：

Shimazaki, Y

Kameo, K

Tanami, T

Tanaka, H

Ono, N

Kiuchi, Y

Okamoto, S

Sato, F

Ichikawa, A

机构：

[1] Taisho Pharmaceut Co Ltd, Med Res Ctr, Ohmiya, Saitama 3308530, Japan

[2] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Kanagawa 2268501, Japan

[3] Kyoto Univ, Fac Pharmaceut Sci, Dept Physiol Chem, Sakyo Ku, Kyoto 6068501, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2000年 / 8卷 / 02期

关键词：

prostaglandins; agonists; receptors; substituent effects;

D O I：

10.1016/S0968-0896(99)00288-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 13,14-didehydro-16-phenoxy analogues of prostaglandin E-1 was synthesized and their agonistic activity on EP receptor subtypes was evaluated. 13,14-Didehydro-16-phenoxy-1-decarboxy analogues, 7e and 7f, display highly selective activity on the EP3 receptor subtype, thus, their utility as a selective anti-ulcer agent can be expected. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：353 / 362

页数：10

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