Production of clinical-grade recombinant adeno-associated virus vectors

被引：39

作者：

Snyder, RO ^{[1
]}

Flotte, TR ^{[1
]}

机构：

[1] Univ Florida, Power Gene Therapy Ctr, Dept Pediat, Gainesville, FL 32610 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0958-1669(02)00369-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recombinant adeno-associated viral (rAAV) vectors are being evaluated in animal models and humans. Pre-clinical data demonstrating vector safety, efficiency and efficacy have been used to initiate human clinical trials. The clinical manufacture of rAAV vectors has supported phase I and phase II trials, showing that adeno-associated virus serotype 2 vectors are safe when administered to humans.

引用

页码：418 / 423

页数：6

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