Innate immunity and toll-like receptors: Clinical implications of basic science research

被引:174
作者
Abreu, MT
Arditi, M
机构
[1] Cedars Sinai Med Ctr, Dept Pediat, Div Pediat Infect Dis, Steven Spielberg Pediat Res Ctr,Burns & Allen Res, Los Angeles, CA 90048 USA
[2] Cedars Sinai Med Ctr, Dept Med, Div Gastroenterol, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90048 USA
[3] Sch Med, Los Angeles, CA 90048 USA
关键词
D O I
10.1016/j.jpeds.2004.01.057
中图分类号
R72 [儿科学];
学科分类号
100202 [儿科学];
摘要
引用
收藏
页码:421 / 429
页数:9
相关论文
共 84 条
[1]
TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells [J].
Abreu, MT ;
Arnold, ET ;
Thomas, LS ;
Gonsky, R ;
Zhou, YH ;
Hu, B ;
Arditi, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (23) :20431-20437
[2]
Decreased expression of toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide [J].
Abreu, MT ;
Vora, P ;
Faure, E ;
Thomas, LS ;
Arnold, ET ;
Arditi, M .
JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1609-1616
[3]
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice [J].
Alexopoulou, L ;
Thomas, V ;
Schnare, M ;
Lobet, Y ;
Anguita, J ;
Schoen, RT ;
Medzhitov, R ;
Fikrig, E ;
Flavell, RA .
NATURE MEDICINE, 2002, 8 (08) :878-884
[4]
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].
Alexopoulou, L ;
Holt, AC ;
Medzhitov, R ;
Flavell, RA .
NATURE, 2001, 413 (6857) :732-738
[5]
[Anonymous], CRIT CARE MED
[6]
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].
Arbour, NC ;
Lorenz, E ;
Schutte, BC ;
Zabner, J ;
Kline, JN ;
Jones, M ;
Frees, K ;
Watt, JL ;
Schwartz, DA .
NATURE GENETICS, 2000, 25 (02) :187-+
[7]
Control of experimental inflammatory bowel disease by regulatory T cells [J].
Asseman, C ;
Fowler, S ;
Powrie, F .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (04) :S185-+
[8]
A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses [J].
Bartfai, T ;
Behrens, MM ;
Gaidarova, S ;
Pemberton, J ;
Shivanyuk, A ;
Rebek, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) :7971-7976
[9]
Control of adaptive immune responses by Toll-like receptors [J].
Barton, GM ;
Medzhitov, R .
CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (03) :380-383
[10]
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition [J].
Bauer, S ;
Kirschning, CJ ;
Häcker, H ;
Redecke, V ;
Hausmann, S ;
Akira, S ;
Wagner, H ;
Lipford, GB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :9237-9242