Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal

被引:38
作者
Cardoso, T. A. M. [1 ]
Coan, A. C. [1 ]
Kobayashi, E. [1 ]
Guerreiro, C. A. M. [1 ]
Li, L. M. [1 ]
Cendes, F. [1 ]
机构
[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Neurol, Fac Ciencias Med, BR-13083970 Campinas, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
TEMPORAL-LOBE EPILEPSY; PROGNOSIS; ATROPHY;
D O I
10.1212/01.wnl.0000223350.08394.06
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors performed hippocampal volumetry and T2 relaxometry in 84 consecutive patients with partial epilepsy from a protocol for antiepileptic drug (AED) withdrawal after at least 2 years of seizure control. Seizure recurrence after AED withdrawal was more frequent among patients with hippocampal atrophy and abnormal hippocampal T2 signal.
引用
收藏
页码:134 / 136
页数:3
相关论文
共 10 条
[1]   Clinical and neuroimaging features of good and poor seizure control patients with mesial temporal lobe epilepsy and hippocampal atrophy [J].
Andrade-Valença, LP ;
Valença, MM ;
Ribeiro, LT ;
Matos, ALM ;
Sales, LV ;
Velasco, TR ;
Santos, AC ;
Leite, JP .
EPILEPSIA, 2003, 44 (06) :807-814
[2]   RELAPSE FOLLOWING DISCONTINUATION OF ANTIEPILEPTIC DRUGS - A METAANALYSIS [J].
BERG, AT ;
SHINNAR, S .
NEUROLOGY, 1994, 44 (04) :601-608
[3]   Is low antiepileptic drug dose effective in long-term seizure-free patients? [J].
Cardoso, TAMO ;
Cendes, F ;
Guerreiro, CAM .
ARQUIVOS DE NEURO-PSIQUIATRIA, 2003, 61 (3A) :566-573
[4]   MRI VOLUMETRIC MEASUREMENT OF AMYGDALA AND HIPPOCAMPUS IN TEMPORAL-LOBE EPILEPSY [J].
CENDES, F ;
ANDERMANN, F ;
GLOOR, P ;
EVANS, A ;
JONESGOTMAN, M ;
WATSON, C ;
MELANSON, D ;
OLIVIER, A ;
PETERS, T ;
LOPESCENDES, I ;
LEROUX, G .
NEUROLOGY, 1993, 43 (04) :719-725
[5]  
Duncan JS, 1996, AM J NEURORADIOL, V17, P1805
[6]  
Guerreiro Carlos A. M., 2000, Epilepsia, V41, P94
[7]   The prognosis for control of seizures with medications in patients with MRI evidence for mesial temporal sclerosis [J].
Kim, WJ ;
Park, SC ;
Lee, SJ ;
Lee, JH ;
Kim, JY ;
Lee, BI ;
Kim, DI .
EPILEPSIA, 1999, 40 (03) :290-293
[8]   Hippocampal atrophy and T2-weighted signal changes in familial mesial temporal lobe epilepsy [J].
Kobayashi, E ;
D'Agostino, MD ;
Lopes-Cendes, I ;
Berkovic, SF ;
Li, ML ;
Andermann, E ;
Andermann, F ;
Cendes, F .
NEUROLOGY, 2003, 60 (03) :405-409
[9]   SOME ASPECTS OF PROGNOSIS IN THE EPILEPSIES - A REVIEW [J].
SANDER, JWAS .
EPILEPSIA, 1993, 34 (06) :1007-1016
[10]   Is the underlying cause of epilepsy a major prognostic factor for recurrence? [J].
Semah, F ;
Picot, MC ;
Adam, C ;
Broglin, D ;
Arzimanoglou, A ;
Bazin, B ;
Cavalcanti, D ;
Baulac, M .
NEUROLOGY, 1998, 51 (05) :1256-1262