Apoptotic and effector pathways in autoimmunity

被引：49

作者：

Chervonsky, AV ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(99)00037-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Programmed cell death is an important anti-autoimmune mechanism used to delete autoreactive lymphocytes and to limit the spread both of viral infections and of tissue damage caused by immune responses. However, in autoimmune diseases, activation of programmed cell death by effector mechanisms that are similar to the normal immune response leads to augmented destruction of the targeted tissues.

引用

收藏

页码：684 / 688

页数：5

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