MicroRNA-31 expression in colorectal serrated pathway progression

被引：11

作者：

Aoki, Hironori ^{[1
]}

Nosho, Katsuhiko ^{[2
]}

Igarashi, Hisayoshi ^{[2
]}

Ito, Miki ^{[2
]}

Mitsuhashi, Kei ^{[2
]}

Naito, Takafumi ^{[2
]}

Yamamoto, Eiichiro ^{[2
]}

Tanuma, Tokuma ^{[1
]}

Nomura, Masafumi ^{[1
]}

Maguchi, Hiroyuki ^{[1
]}

Shinohara, Toshiya ^{[3
]}

Suzuki, Hiromu ^{[4
]}

Yamamoto, Hiroyuki ^{[5
]}

Shinomura, Yasuhisa ^{[2
]}

机构：

[1] Teine Keijinkai Hosp, Ctr Gastroenterol, Sapporo, Hokkaido 0060811, Japan

[2] Sapporo Med Univ, Sch Med, Dept Gastroenterol Rheumatol & Clin Immunol, Sapporo, Hokkaido 0608543, Japan

[3] Teine Keijinkai Hosp, Dept Pathol, Sapporo, Hokkaido 0060811, Japan

[4] Sapporo Med Univ, Sch Med, Dept Mol Biol, Sapporo, Hokkaido 0608543, Japan

[5] St Marianna Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Kawasaki, Kanagawa 2168511, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 34期

基金：

日本学术振兴会;

关键词：

BRAF; Colorectal carcinoma; MicroRNA-31; MLH1; microsatellite instability; Serrated pathway; LESIONS; CANCER;

D O I：

10.3748/wjg.v20.i34.12346

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers (CRC). We have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC. Moreover, high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps (HPs). These results suggest that miR-31 may contribute to the progression of serrated lesions. At a follow-up colonoscopy, we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features. Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component. Higher miR-31 expression was observed in the carcinoma component (57-fold increase) and the HP component (8-fold increase) compared with the paired normal mucosa, suggesting that miR-31 may be one of the key molecules in serrated pathway progression. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：12346 / 12349

页数：4

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