Exercise echocardiography in postmenopausal hormone users with mild systemic hypertension

被引:45
作者
Pines, A
Fisman, EZ
Shapira, I
Drory, Y
Weiss, A
Eckstein, N
Levo, Y
Averbuch, M
Motro, M
Rotmensch, HH
Ayalon, D
机构
[1] TEL AVIV UNIV, ELIAS SOURASKY MED CTR, DEPT MED E, TIMSIT INST REPROD ENDOCRINOL, IL-62439 TEL AVIV, ISRAEL
[2] TEL AVIV UNIV, ELIAS SOURASKY MED CTR, DEPT CARDIOL, IL-62439 TEL AVIV, ISRAEL
[3] CHAIM SHEBA MED CTR, CARDIAC REHABIL INST, IL-52621 TEL HASHOMER, ISRAEL
[4] RAMAT MARPE HOSP, MENOPAUSE CLIN, RAMAT GAN, ISRAEL
关键词
D O I
10.1016/S0002-9149(96)00646-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Rest and exercise echocardiography (at dynamic and isometric exercise) were performed in 30 postmenopausal women (aged 54+/-4 years) with borderline to mild hypertension. They were then divided into 2 groups: 17 women who started oral hormone replacement therapy (0.625 mg/day conjugated estrogens or 2 mg/day estradiol) and a control group of 13 nonusers. After 6 to 9 months, a second echocardiography was performed in 26 women (4 withdrew). There were only a few changes in values obtained in the 12 controls at the end of follow-vp compared with baseline. Primarily, these changes included a slight decrease in systolic blood pressure at rest and on exercise. Several significant morphologic and hemodynamic alterations appeared in 14 hormone users. Left ventricular cavity dimensions and mass became smaller: mean end-diastolic diameter decreased from 45.9+/-3 mm at baseline to 44.4+/-3 mm at study termination (p=0.007). The corresponding values for end-systolic diameter were 25.8+/-4 mm and 23.9+/-4 mm (p=0.006); for left atrium diameter, it was 34.5+/-4 mm and 32.5+/-4 mm (p= 0.001); for left ventricular wall width, it was 19.9+/-2 mm and 19.3+/-2 mm (p=0.02); for left ventricular mass, it was 197+/-28 g and 179+/-32 g (p=0.006). The resting aortic blood flow velocity and acceleration increased: 119+/-18 cm/s before therapy versus 129+/- 23 cm/s while on hormone substitution (p=0.04), and 13.6+/-3 m/s(2) versus 16.5+/-4 m/s(2) (p=0.008), respectively. Mean rest to peak exercise systolic blood pressure difference became smaller after hormones: 39 +/-19 mm Hg versus 28+/-13 mm Hg (p=0.03) during dynamic exercise, and 43+/-22 mm Hg versus 25+/-13 mm Hg (p=0.004) during isometric exercise. The above data probably indicate that with hormone replacement therapy, there is an improvement in cardiac function both at rest and during exercise. (C) 1996 by Excerpta Medica, Inc.
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收藏
页码:1385 / 1389
页数:5
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