The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus

被引：54

作者：

Eriksson, JG

Forsén, TJ

Mortensen, SA

Rohde, M

机构：

[1] Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Helsinki 00300, Finland

[2] Rigshosp, Dept Med B, DK-2100 Copenhagen, Denmark

[3] Rigshosp, Dept Clin Pharmacol Q, DK-2100 Copenhagen, Denmark

来源：

BIOFACTORS | 1999年 / 9卷 / 2-4期

关键词：

D O I：

10.1002/biof.5520090229

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A possible relationship between the pathogenesis of type 2 diabetes and coenzyme Q(10) (CoQ(10),) deficiency has been proposed. The aim of this study was to assess the effect of CoQ(10) on metabolic control in 23 type 2 diabetic patients in a randomized, placebo-controlled trial. Treatment with CoQ(10) 100 mg bid caused a more than 3-fold rise in serum CoQ(10) concentration(p < 0.001). No correlation was observed between serum CoQ(10) concentration and metabolic control. No significant changes in metabolic parameters were observed during CoQ(10), supplementation. The treatment was well tolerated and did not interfere with glycemic control, therefore CoQ(10) may be used as adjunctive therapy in patients with associated cardiovascular diseases.

引用

页码：315 / 318

页数：4

共 13 条

[1]

ANDERSEN CB, 1997, MOL ASPECTS MED S, V18, P307

[2] DIET AND EXERCISE IN THE TREATMENT OF NIDDM - THE NEED FOR EARLY EMPHASIS [J].