One antigen mismatched related donor bone marrow transplant in a patient with acute lymphoblastic leukaemia and β-thalassaemia major:: potential cure of both marrow disorders

被引：12

作者：

Kottaridis, PD

Peggs, K

Lawrence, A

Verfuerth, S

Chatterjee, R

Telfer, P

Porter, JB

Mackinnon, S

Goldstone, AH

机构：

[1] UCL Hosp, Dept Haematol, London WC1E 6AU, England

[2] UCL Hosp, Dept Reprod Med Unit, London WC1E 6AU, England

[3] Royal London Hosp, Dept Haematol, London E1 1BB, England

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 25卷 / 06期

关键词：

thalassaemia major; acute lymphoblastic leukaemia; bone marrow transplantation;

D O I：

10.1038/sj.bmt.1702213

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We report a case of a 34-year-old man with T-ALL and beta-thalassaemia major who underwent a one antigen mismatched related donor bone marrow transplant. Five months post transplant chimeric studies revealed full donor haemopoiesis and the patient remains leukaemia and thalassaemia free at 12 months post transplant. Cumulative risk factors contributing to the increased transplant-related mortality in patients with two different marrow disorders are discussed.

引用

页码：677 / 678

页数：2

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