Participation of CaMKII in neuronal plasticity and memory formation

被引：53

作者：

Cammarota, M

Bevilaqua, LRM

Viola, H

Kerr, DS

Reichmann, B

Teixeira, V

Bulla, M

Izquierdo, I

Medina, JH

机构：

[1] Univ Fed Rio Grande do Sul, ICBS, Dept Bioquim, Ctr Memoria, BR-90035003 Porto Alegre, RS, Brazil

[2] UBA, Fac Med, Inst Biol Celular & Neurociencias Prof Dr Eduardo, Buenos Aires, DF, Argentina

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2002年 / 22卷 / 03期

关键词：

CaMKII; memory; synaptic plasticity;

D O I：

10.1023/A:1020763716886

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. The unique biochemical properties of Ca2+/calmodulin (CaM)-dependent protein kinase II have made this enzyme one of the paradigmatic models of the forever searched "memory molecule." 2. In particular, the central participation of CaMKII as a sensor of the Ca2+ signals generated by activation of NMDA receptors after the induction of long-term plastic changes, has encouraged the use of pharmacological, genetic, biochemical, and imaging tools to unveil the role of this kinase in the acquisition, consolidation, and expression of different types of memories. 3. Here we review some of the more exciting discoveries related to the mechanisms involved in CaMKII activation and synaptic plasticity.

引用

页码：259 / 267

页数：9

共 68 条

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