Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2

被引：26

作者：

Kubota, H ^{[1
]}

Matsumoto, S ^{[1
]}

Yokota, S ^{[1
]}

Yanagi, H ^{[1
]}

Yura, T ^{[1
]}

机构：

[1] HSP Res Inst, Shimogyo Ku, Kyoto 6008813, Japan

来源：

FEBS LETTERS | 1999年 / 461卷 / 1-2期

关键词：

chaperonin containing TCP-1; heat shock factor; molecular chaperone; transcription factor; transcriptional regulation;

D O I：

10.1016/S0014-5793(99)01437-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chaperonin containing TCP-1 (CCT) is a eukaryotic molecular chaperone consisting of eight subunit species and assists in the folding of cytosolic proteins. We show here that all eight mouse CCT subunit genes contain sequences called heat shock elements for binding heat shock transcription factors (HSFs) by electrophoretic mobility shift assays and that these genes are transcriptionally activated by HSFs in reporter gene assays using HeLa cells transiently overexpressing HSFs. These results suggest that HSF1 and/or HSF2 play a role in Cct gene expression. (C) 1999 Federation of European Biochemical Societies.

引用

页码：125 / 129

页数：5

共 47 条

[1] HEAT SHOCK-INDUCED INTERACTIONS OF HEAT-SHOCK TRANSCRIPTION FACTOR AND THE HUMAN HSP70 PROMOTER EXAMINED BY INVIVO FOOTPRINTING [J].