Sequestration of Mycobacterium tuberculosis in tight vacuoles in vivo in lung macrophages of mice infected by the respiratory route

被引:46
作者
Moreira, AL [1 ]
Wang, J [1 ]
TsenovaBerkova, L [1 ]
Hellmann, W [1 ]
Freedman, VH [1 ]
Kaplan, G [1 ]
机构
[1] ROCKEFELLER UNIV,CELLULAR PHYSIOL & IMMUNOL LAB,NEW YORK,NY 10021
关键词
D O I
10.1128/IAI.65.1.305-308.1997
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Following aerosol infection of mice with Mycobacterium tuberculosis, single mycobacteria or pairs of bacilli were observed within individual phagocytic vacuoles bound by tightly apposed vacuolar membranes. The virulent organism was not observed free in the cytoplasm of the parasitized cells or in the extracellular space of the lung granulomata. This study indicates that in vivo, virulent mycobacteria survive and probably replicate within a unique tight vacuole in the infected phagocyte within the lung.
引用
收藏
页码:305 / 308
页数:4
相关论文
共 11 条
[1]   PHAGOSOME-LYSOSOME INTERACTIONS IN CULTURED MACROPHAGES INFECTED WITH VIRULENT TUBERCLE-BACILLI - REVERSAL OF USUAL NONFUSION PATTERN AND OBSERVATIONS ON BACTERIAL SURVIVAL [J].
ARMSTRONG, JA ;
HART, PD .
JOURNAL OF EXPERIMENTAL MEDICINE, 1975, 142 (01) :1-16
[2]   Nonadherent cultures of human monocytes kill Mycobacterium smegmatis, but adherent cultures do not [J].
Barker, K ;
Fan, HX ;
Carroll, C ;
Kaplan, G ;
Barker, J ;
Hellmann, W ;
Cohn, ZA .
INFECTION AND IMMUNITY, 1996, 64 (02) :428-433
[3]   CHARACTERIZATION OF THE MYCOBACTERIUM-TUBERCULOSIS PHAGOSOME AND EVIDENCE THAT PHAGOSOMAL MATURATION IS INHIBITED [J].
CLEMENS, DL ;
HORWITZ, MA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :257-270
[4]  
HART PD, 1974, INFECT IMMUN, V10, P762
[5]   PATHOGENESIS OF TUBERCULOSIS - INTERACTION OF MYCOBACTERIUM-TUBERCULOSIS WITH MACROPHAGES [J].
MCDONOUGH, KA ;
KRESS, Y ;
BLOOM, BR .
INFECTION AND IMMUNITY, 1993, 61 (07) :2763-2773
[6]   APOPTOSIS, BUT NOT NECROSIS, OF INFECTED MONOCYTES IS COUPLED WITH KILLING OF INTRACELLULAR BACILLUS-CALMETTE-GUERIN [J].
MOLLOY, A ;
LAOCHUMROONVORAPONG, P ;
KAPLAN, G .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1499-1509
[7]  
NORTH RJ, 1909, J INFECT DIS, V172, P1550
[8]  
Orme Ian M., 1994, P113
[9]   Comparable growth of virulent and avirulent Mycobacterium tuberculosis in human macrophages in vitro [J].
Paul, S ;
Laochumroonvorapong, P ;
Kaplan, G .
JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (01) :105-112
[10]   LACK OF ACIDIFICATION IN MYCOBACTERIUM PHAGOSOMES PRODUCED BY EXCLUSION OF THE VESICULAR PROTON-ATPASE [J].
STURGILLKOSZYCKI, S ;
SCHLESINGER, PH ;
CHAKRABORTY, P ;
HADDIX, PL ;
COLLINS, HL ;
FOK, AK ;
ALLEN, RD ;
GLUCK, SL ;
HEUSER, J ;
RUSSELL, DG .
SCIENCE, 1994, 263 (5147) :678-681