Protein splicing: Occurrence, mechanisms and related phenomena

被引:41
作者
Shao, Y
Kent, SBH
机构
[1] Gryphon Sciences, South San Francisco, CA 94080
来源
CHEMISTRY & BIOLOGY | 1997年 / 4卷 / 03期
关键词
D O I
10.1016/S1074-5521(97)90287-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
An increasing number of proteins are thought to self-splice post-translationally on the level of the polypeptide, producing two separate proteins from one gene, neither of which is the protein predicted from the gene sequence. The recent elucidation of the mechanism of splicing has led to the identification of a number of post-translational protein modifications that use similar chemical pathways.
引用
收藏
页码:187 / 194
页数:8
相关论文
共 47 条
[1]   A STING IN THE (M-TERMINAL) TAIL [J].
ARTYMIUK, PJ .
NATURE STRUCTURAL BIOLOGY, 1995, 2 (12) :1035-1037
[2]   The synthesis of alpha,beta-diglyceridene and asymmetrical triglyceridene. [J].
Bergmaun, M ;
Brand, E ;
Dreyer, F .
BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1921, 54 :936-965
[3]   Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii [J].
Bult, CJ ;
White, O ;
Olsen, GJ ;
Zhou, LX ;
Fleischmann, RD ;
Sutton, GG ;
Blake, JA ;
FitzGerald, LM ;
Clayton, RA ;
Gocayne, JD ;
Kerlavage, AR ;
Dougherty, BA ;
Tomb, JF ;
Adams, MD ;
Reich, CI ;
Overbeek, R ;
Kirkness, EF ;
Weinstock, KG ;
Merrick, JM ;
Glodek, A ;
Scott, JL ;
Geoghagen, NSM ;
Weidman, JF ;
Fuhrmann, JL ;
Nguyen, D ;
Utterback, TR ;
Kelley, JM ;
Peterson, JD ;
Sadow, PW ;
Hanna, MC ;
Cotton, MD ;
Roberts, KM ;
Hurst, MA ;
Kaine, BP ;
Borodovsky, M ;
Klenk, HP ;
Fraser, CM ;
Smith, HO ;
Woese, CR ;
Venter, JC .
SCIENCE, 1996, 273 (5278) :1058-1073
[4]   Protein splicing involving the Saccharomyces cerevisiae VMA intein - The steps in the splicing pathway, side reactions leading to protein cleavage, and establishment of an in vitro splicing system [J].
Chong, SR ;
Shao, Y ;
Paulus, H ;
Benner, J ;
Perler, FB ;
Xu, MQ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (36) :22159-22168
[5]   A PROPOSED MECHANISM FOR THE SELF-SPLICING [J].
CLARKE, ND .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) :11084-11088
[6]   PROTEIN SPLICING OF THE YEAST TFP1 INTERVENING PROTEIN-SEQUENCE - A MODEL FOR SELF-EXCISION [J].
COOPER, AA ;
CHEN, YJ ;
LINDORFER, MA ;
STEVENS, TH .
EMBO JOURNAL, 1993, 12 (06) :2575-2583
[7]   PROTEIN SPLICING - SELF-SPLICING OF GENETICALLY MOBILE ELEMENTS AT THE PROTEIN LEVEL [J].
COOPER, AA ;
STEVENS, TH .
TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (09) :351-356
[8]   EVIDENCE OF SELECTION FOR PROTEIN INTRONS IN THE RECAS OF PATHOGENIC MYCOBACTERIA [J].
DAVIS, EO ;
THANGARAJ, HS ;
BROOKS, PC ;
COLSTON, MJ .
EMBO JOURNAL, 1994, 13 (03) :699-703
[9]   PROTEIN SPLICING IN THE MATURATION OF MYCOBACTERIUM-TUBERCULOSIS RECA PROTEIN - A MECHANISM FOR TOLERATING A NOVEL CLASS OF INTERVENING SEQUENCE [J].
DAVIS, EO ;
JENNER, PJ ;
BROOKS, PC ;
COLSTON, MJ ;
SEDGWICK, SG .
CELL, 1992, 71 (02) :201-210
[10]   NOVEL STRUCTURE OF THE RECA LOCUS OF MYCOBACTERIUM-TUBERCULOSIS IMPLIES PROCESSING OF THE GENE-PRODUCT [J].
DAVIS, EO ;
SEDGWICK, SG ;
COLSTON, MJ .
JOURNAL OF BACTERIOLOGY, 1991, 173 (18) :5653-5662